{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:11:54Z","timestamp":1780315914974,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Airway clearance is major part of care for children with bronchiectasis (BE) and oscillatory positive pressure (OPEP) devices are widely used, yet their added value beyond a multicomponent chest physiotherapy (CPT) program remains unclear and device access often entails out of pocket costs. Aim of this study was to evaluate whether adding an OPEP device to a multicomponent CPT program provides additional benefits in exercise capacity and dynamic ventilatory responses in children with BE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized trial involving 42 children with non\u2010cystic fibrosis BE was conducted. Children were allocated to either CPT or CPT\u2009+\u2009OPEP group. Both groups trained at home twice daily for 8 weeks. 6\u2010min walk test (6MWT) with Spiropalm\u00ae device, spirometry, quadriceps strength measurement and Leicester Cough Questionnaire (LCQ) were applied at baseline and after training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      6MWT distance, change in inspiratory capacity during exertion (\u0394IC), lowest SpO\n                      <jats:sub>2<\/jats:sub>\n                      , the time spent with a drop of \u2265\u2009%4 in SpO\n                      <jats:sub>2<\/jats:sub>\n                      [T (dSpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009\u2265\u2009%4)], FVC%, FEV\n                      <jats:sub>1<\/jats:sub>\n                      %, PEF%, significantly improved in both groups, with no between\u2010groups difference. Program adherence (%) was significantly higher in CPT\u2009+\u2009OPEP group (85\u2009\u00b1\u200915) compared to CPT group (74\u2009\u00b1\u200918) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children with BE, a multicomponent CPT program improved exercise capacity, dynamic ventilatory responses and spirometry, while adding an OPEP device primarily increased adherence and conferred no additional benefit. The decision to add an OPEP device may be individualized to address engagement or feasibility rather than further clinical benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The study was prospectively registered to ClinicalTrials. gov on September 1, 2021, under the registration number NCT05034900.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71602","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:45:02Z","timestamp":1774950302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Benefits in Children With Bronchiectasis?: A Randomized Trial"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-315X","authenticated-orcid":false,"given":"Melih","family":"Zeren","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Izmir Bakircay University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-1733","authenticated-orcid":false,"given":"Meral","family":"Barlik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Mersin City Training and Research Hospital Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza Nur Caglar","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Graduate Education Institute Izmir Bakircay University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Gulen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02990-2020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.06.040"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008351.pub3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13459"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27370"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41030-021-00178-1"},{"issue":"4","key":"e_1_2_13_9_1","article-title":"Oscillating Devices for Airway Clearance in People With Cystic Fibrosis","volume":"4","author":"Morrison L.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-098742"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00233-3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26028"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.339"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04509-5"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.01.013"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"issue":"1","key":"e_1_2_13_20_1","article-title":"Airway Clearance Techniques for Cystic Fibrosis: An Overview of Cochrane Systematic Reviews","volume":"1","author":"Wilson L. M.","year":"2019","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"e_1_2_13_21_1","article-title":"Airway Clearance Techniques Compared to no Airway Clearance Techniques for Cystic Fibrosis","volume":"4","author":"Warnock L.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"e_1_2_13_22_1","article-title":"Exercise Training for Bronchiectasis","volume":"4","author":"Lee A. L.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26026"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25259"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.11.005"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00301103"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02053-2022"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2022.2126741"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01689-2023"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.04.011"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2007.02.002"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-024-10550-x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71602","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:32:47Z","timestamp":1780313567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ppul.71602"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71602","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71602"}}