{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:09:56Z","timestamp":1780315796117,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Childhood interstitial lung disease (chILD) refers to a rare and heterogeneous group of disorders that can arise from genetic or acquired causes. Interstitial lung involvement due to metabolic diseases is a rare but significant condition among chILD cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective descriptive study analyzed data from the chILD\u2010Turkey registry, established in November 2021, including patients registered until August 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 28 patients (3.9% of 706 children in the registry) were included, with lysosomal storage diseases (LSDs) accounting for 25 cases (89.3%) and Niemann\u2010Pick disease (NP) being the most common diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916, 57.1%), followed by Gaucher disease (GD) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097, 25.0%). The mortality rate during the 3\u2010year follow\u2010up was 10.7% (3\/28). Computed tomography (CT) most commonly revealed interlobular septal thickening (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917, 60.7%). No statistically significant differences in CT findings were observed between symptomatic and asymptomatic patients at the time of diagnosis. The most frequent variant in NP was c.416\u2009T\u2009&gt;\u2009C in\n                      <jats:italic>SMPD1<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094, 25%), and in GD, c.1448\u2009T\u2009&gt;\u2009C was identified in four patients (57.1%). Eight patients (2 NP and 6 GD) received enzyme replacement therapy (ERT). No increase in respiratory support needs was observed under ERT, and one patient showed significant regression in CT findings during follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>chILD in metabolic disorders often progresses insidiously, resulting in delayed diagnosis. While management is mostly supportive, early ERT may improve or stabilize lung disease in selected cases. Further prospective studies are needed to clarify the impact of ERT and substrate reduction therapy (SRT) on long\u2010term pulmonary outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71603","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:58:38Z","timestamp":1775221118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood Interstitial Lung Disease in Metabolic Disorders: Prevalence, Genotypic and Clinical Characteristics, and Management Approaches: An Analysis of the Child\u2010Turkey Registry"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-3966","authenticated-orcid":false,"given":"Merve Sel\u00e7uk","family":"Balc\u0131","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology Marmara University Faculty of Medicine Istanbul 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