{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:22:04Z","timestamp":1788211324257,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Extrapulmonary effects are observed in patients with primary ciliary dyskinesia (PCD), however, few studies have examined these manifestations, particularly regarding balance and muscle oxygenation during exercise. This study aimed to compare balance, functional exercise capacity, muscle oxygenation, respiratory and peripheral muscle strength, and inspiratory muscle endurance in patients with PCD and healthy peers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients with PCD and 26 healthy peers were included. Balance (Biodex Balance System and Y Balance Test), exercise capacity (6\u2010min walk test [6MWT]), muscle oxygenation (Moxy device), respiratory muscle strength (maximal inspiratory [MIP] and maximal expiratory [MEP]), inspiratory muscle endurance (incremental threshold loading test), and muscle strength (quadriceps femoris) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Y balance test right and left lower extremity posteromedial and posterolateral scores and left lower extremity posteromedial and posterolateral reach distances, the 6MWT distance, and lower extremity muscle strength (%), were statistically lower in patients with PCD compared with healthy peers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The change in average quadriceps femoris muscle oxygenation (\u0394SmO\n                      <jats:sub>2averaged<\/jats:sub>\n                      ) during the 6MWT was higher in patients with PCD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). MIP, MEP, inspiratory muscle endurance, postural stability indices, and other parameters of the Y balance test were similar between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In patients with PCD, dynamic balance, functional exercise capacity, and lower extremity muscle strength are impaired, whereas respiratory muscle strength and static balance are preserved. Inspiratory muscle endurance was similarly decreased in both groups. A greater decrease in muscle oxygen saturation was observed during submaximal lower extremity activity in the patients. These findings indicate that, beyond traditional respiratory evaluations, balance and muscle oxygenation should be assessed in patients with PCD, and early assessment may guide rehabilitation strategies and future clinical research.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT04895150\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71605","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:19:28Z","timestamp":1775200768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Balance Impairment, Muscle Oxygenation, and Functional Exercise Capacity in Patients With Primary Ciliary Dyskinesia"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-2631","authenticated-orcid":false,"given":"\u015eeyma","family":"Mutlu Kayaarslan","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences Ba\u015fkent University Ankara T\u00fcrkiye"},{"name":"Department of Physical Therapy and Rehabilitation, Graduate School of Health Sciences Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-9912","authenticated-orcid":false,"given":"Meral","family":"Bo\u015fnak G\u00fc\u00e7l\u00fc","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-4999","authenticated-orcid":false,"given":"Tu\u011fba","family":"\u015ei\u015fmanlar Ey\u00fcbo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Chest Diseases, Faculty of Medicine Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-8517","authenticated-orcid":false,"given":"Ay\u015fe Tana","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Chest Diseases, Faculty of Medicine Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09593985.2013.820246"},{"key":"e_1_2_12_3_1","first-page":"1233","article-title":"Postural Control in Chronic Obstructive Pulmonary Disease: A Systematic Review","volume":"10","author":"Porto E. 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