{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:31:44Z","timestamp":1788820304771,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Primary ciliary dyskinesia (PCD) is a phenotypically diverse disease; the impact of nutritional status on clinical trajectories in patients with PCD is not well defined. The aim of this study is to examine the impact of malnutrition on lung function in a pediatric cohort of patients with PCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study of pediatric patients with a confirmed diagnosis of PCD at the Hospital for Sick Children in Toronto, Canada between 2000 and 2022. Undernutrition was defined as a BMI\u2010 or weight\u2010for\u2010age z\u2010score &lt;\u2009\u20101. Mixed effects linear regression models were used to assess the effect of undernutrition on FEV\n                      <jats:sub>1<\/jats:sub>\n                      z\u2010score (zFEV\n                      <jats:sub>1<\/jats:sub>\n                      ) over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six patients with a median age at diagnosis of 7 years (IQR 3, 12) were included. Mean (SD) BMI\u2010for\u2010age z\u2010score at first encounter was 0.15 (1.51), and weight\u2010for\u2010age z\u2010score 0.00 (1.42). On a per visit basis, a BMIz or WFAz of &lt;\u2009\u20101 was associated with a 0.21 lower zFEV\n                      <jats:sub>1<\/jats:sub>\n                      (95% CI \u22120.35, \u22120.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Patients who had at least one encounter with undernutrition had a zFEV\n                      <jats:sub>1<\/jats:sub>\n                      1.30 lower overall than patients who were consistently well\u2010nourished (95% CI: \u22121.72, \u22120.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no significant difference in the rate of FEV\n                      <jats:sub>1<\/jats:sub>\n                      decline or time to next exacerbation between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In pediatric patients with PCD, undernutrition was associated with a significantly lower FEV\n                      <jats:sub>1<\/jats:sub>\n                      , both at individual encounters and when compared to consistently well\u2010nourished individuals. There was no significant difference in the rate of FEV\n                      <jats:sub>1<\/jats:sub>\n                      decline in patients who were undernourished.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71634","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T15:59:06Z","timestamp":1776614346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Nutritional Status on Lung Function Trajectories in Pediatric Patients With Primary Ciliary Dyskinesia"],"prefix":"10.1002","volume":"61","author":[{"given":"Jacob","family":"McCoy","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-5115","authenticated-orcid":false,"given":"Dvir","family":"Gatt","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-6779","authenticated-orcid":false,"given":"Michelle","family":"Shaw","sequence":"additional","affiliation":[{"name":"Translational Medicine, Research Institute, The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0155-7377","authenticated-orcid":false,"given":"Fiona","family":"Kritzinger","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ratjen","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine The Hospital for Sick Children University of Toronto Toronto Ontario Canada"},{"name":"Translational Medicine, Research Institute, The Hospital for Sick Children Toronto Ontario 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