{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:46:18Z","timestamp":1793018778991,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) in infants. In 2024, the monoclonal antibody nirsevimab became available in Italy for all newborns during their first RSV season.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aims were to assess whether the introduction of nirsevimab was associated with changes in respiratory virus circulation and hospitalization rates among children admitted with bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted, comparing two epidemic seasons: pre\u2010nirsevimab (2023\u20132024) and post\u2010nirsevimab (2024\u20132025). All infants under 12 months hospitalized for bronchiolitis were included. Viral detection was performed using multiplex PCR on a nasopharyngeal swab. Emergency department visits, pediatric ward, and PICU admissions were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 168 patients with bronchiolitis were enrolled across the two epidemic seasons, with 119 cases in the pre\u2010nirsevimab season and 49 in the post\u2010nirsevimab season. Regarding virus circulation, influenza virus cases increased from 5\/119 (4.2%) in the pre\u2010nirsevimab season to 7\/48 (14.6%) in the post\u2010nirsevimab season. Bocavirus was not detected during the pre\u2010nirsevimab season (0\/119) but was identified in 4\/48 cases (8.3%) in the post\u2010nirsevimab season.<\/jats:p>\n                    <jats:p>\n                      RSV\u2010related hospitalizations decreased in the post\u2010nirsevimab season, corresponding to a 59% reduction (95% CI 0.30\u20130.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in pediatric ward admissions.\n                    <\/jats:p>\n                    <jats:p>\n                      Similarly, the number of ED visits and PICU admissions for bronchiolitis decreased substantially, with reductions of 52% (95% CI 0.39\u20130.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 60% (95% CI 0.17\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), respectively. Hospitalized infants were significantly older, with a marked reduction in admissions among those \u2264\u20093 months of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nirsevimab has proven effective in reducing severe RSV\u2010related bronchiolitis, significantly easing the burden on healthcare systems during RSV epidemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71647","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:24:01Z","timestamp":1778937841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Virus Detection and Hospitalization Rate in Infants With Bronchiolitis After Nirsevimab Introduction: A Retrospective Comparative Two\u2010Season Study"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-8920","authenticated-orcid":false,"given":"Domenico Paolo","family":"La Regina","sequence":"first","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Spatuzzo","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enea","family":"Bonci","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-3462","authenticated-orcid":false,"given":"Raffaella","family":"Nenna","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-2981","authenticated-orcid":false,"given":"Laura","family":"Petrarca","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giulia","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Mancino","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-360X","authenticated-orcid":false,"given":"Alessandra","family":"Pierangeli","sequence":"additional","affiliation":[{"name":"Department of Virology and Microbiology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Virology and Microbiology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Midulla","sequence":"additional","affiliation":[{"name":"Department of Maternal Child and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413456"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115733963267129230919091338"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25919"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004038"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"01","article-title":". \u201c12 Comma 5 Del Decreto\u2010Legge 13 Settembre 2012 n. 158 Convertito Nella Legge 8 Novembre 2012 n. 189","volume":"9","author":"Classificazione di medicinali per uso umano ai sensi dell'art","year":"2023","journal-title":"Agenzia Italiana del Farmaco (AIFA)"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110275"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913556"},{"key":"e_1_2_9_11_1","unstructured":"Programma di immunizzazione contro il Virus Respiratorio Sinciziale (VRS) in et\u00e0 pediatrica. \u201cIntesa Stato\u2010Regioni del 17 ottobre 2024 (Rep. Atti n. 188\/CSR). Nuove indicazioni operative.\u201d Regione Lazio Registro Ufficiale u.1379124 08.11.2024."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12122403"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004314"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-025-00199-2"},{"issue":"03","key":"e_1_2_9_15_1","first-page":"10","article-title":"Virus Respiratorio Sinciziale: Strategia Di Prevenzione Universale Della Bronchiolite Nelle Regioni Italiane","volume":"03","year":"2025","journal-title":"Societ\u00e0 Italiana di Pediatria, Rivista SIP"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400046"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(25)00093-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.4.2400033"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71647","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:10:57Z","timestamp":1784725857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ppul.71647"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71647","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71647"}}