{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:25:38Z","timestamp":1786116338003,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic fibrosis (CF) is a rare, multisystem genetic disease requiring early diagnosis and lifelong multidisciplinary follow\u2010up. In many middle\u2010income countries, including Colombia, national CF registries are absent, and epidemiological information largely relies on administrative health data. Although such data do not reflect true clinical prevalence, they enable systematic monitoring of service\u2010based prevalence and diagnostic practice patterns, offering critical insights for health system planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide, observational study using the Colombian Individual Registry of Provision of Health Services (RIPS) from 2015 to 2024. Children and adolescents aged 0\u201319 years with CF diagnoses (ICD\u201010 E84.0\u2013E84.9) were identified. Annual crude and age\u2010standardized administrative prevalence rates were estimated using national population projections. Diagnostic test utilization (spirometry, chest CT, pancreatic elastase, genetic testing) was quantified per 100 encounters. Temporal trends were analyzed using LOESS smoothing with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The age\u2010standardized national administrative prevalence of CF\u2010related healthcare encounters was 5.64 per 100,000. Administrative prevalence was highest in children aged 0\u20134 years and declined progressively with age. The contributory insurance regime showed the highest service\u2010based prevalence, suggesting disparities in diagnostic access. Temporal patterns revealed a peak in 2018\u20132019 followed by a decline after 2020, coinciding with COVID\u201019\u2013related disruptions in pediatric care. Diagnostic utilization was markedly low: spirometry was performed in fewer than 6 tests per 100 encounters annually, chest CT use was sporadic, and genetic testing was minimal before 2018, increasing slightly thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administrative prevalence of CF in Colombia has remained stable over a decade but is accompanied by underutilization of essential diagnostic procedures and inequities across insurance groups. Strengthening diagnostic capacity, standardizing monitoring practices, and improving early detection are urgent priorities. This study provides a scalable framework for CF surveillance in countries lacking national registries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71717","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:08:13Z","timestamp":1782720493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Administrative Prevalence and Healthcare Utilization of Pediatric Cystic Fibrosis in a Middle\u2010Income Country: A 10\u2010Year Analysis of National Administrative Data"],"prefix":"10.1002","volume":"61","author":[{"given":"Jefferson Antonio","family":"Buend\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Grupo de Investigaci\u00f3n en Farmacolog\u00eda y Toxicolog\u00eda Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Program Hospital Universitario San Jose Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003329"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.08.012"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"356","article-title":"Policymaking Through Healthcare Registries in Sweden","volume":"33","author":"\u00d6rnerheim M.","year":"2018","journal-title":"Health Promotion International"},{"key":"e_1_2_9_5_1","unstructured":"SISPRO\u2014Sistema Integrado de Informaci\u00f3n de la Protecci\u00f3n Social Ministerio de Salud 2025 https:\/\/www.sispro.gov.co\/Pages\/Home.aspx."},{"key":"e_1_2_9_6_1","unstructured":"Social MdSyP. Cifras de Aseguramiento en Salud 2025 https:\/\/www.minsalud.gov.co\/proteccionsocial\/Paginas\/cifras-aseguramiento-salud.aspx."},{"key":"e_1_2_9_7_1","unstructured":"Colombia D. Censo Nacional de Poblaci\u00f3n y Vivienda\u2014Poblaci\u00f3n Por Edad y Sexo 2018. 2025."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reumae.2020.07.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12300"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0370-41062017000400004"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"175","article-title":"[Analysis of Needs and Use of Mental Healthcare Services in Colombia]","volume":"21","author":"Zamora\u2010Rondon D. C.","year":"2019","journal-title":"Revista de Salud P\u00fablica (Bogot\u00e1, Colombia)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04387-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319864168"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.12.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.040"},{"key":"e_1_2_9_16_1","unstructured":"Cystic Fibrosis Foundation. Cystic Fibrosis Foundation Patient Registry Annual Data Report. Bethesda MD; 2022. 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