{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:57:01Z","timestamp":1793318221117,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to identify early clinical predictors of non\u2010invasive ventilation (NIV) failure in children with Pediatric Acute Respiratory Distress Syndrome (PARDS) and to develop a model to predict NIV outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational study including children (0\u221215 years) who were supported by NIV and met PARDS criteria was performed in two public PICUs in Chile. Demographic, physiological variables, and clinical outcomes were recorded. Logistic regression was used to identify risk factors for NIV failure and develop a predictive model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010six patients were enrolled (median age 22 months [IQR 11\u201348]; weight 12.1\u2009kg [9.6\u201318.3]). Eighteen patients (24%) failed NIV (Failure group), with a median NIV duration of 12.5\u2009h (IQR 8\u201323.8). The Failure group showed a significant reduction in the SpO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio after 2\u2009h of NIV (\u221259 [\u2212124 to 5] vs \u22122 [\u221249 to 30],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). In multivariate analysis, an increase in \u0394SpO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      (improvement in oxygenation) was associated with lower odds of NIV failure (OR 0.98; 95% CI 0.97\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), indicating that worsening oxygenation was associated with a higher risk. The final prediction model included age and early changes in SpO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      , respiratory rate, and heart rate, demonstrating good discrimination (AUROC 0.764; 95% CI 0.641\u20130.888).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children with PARDS treated with NIV, a model including age and early changes in oxygenation, heart rate, and respiratory rate within the first 2\u2009h predicts the need for intubation with good discrimination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71723","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:24:31Z","timestamp":1782908671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Oxygenation Trajectory and Noninvasive Ventilation Failure in Non\u2010Immunocompromised Children With Pediatric ARDS"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-759X","authenticated-orcid":false,"given":"Fernando","family":"Bustos\u2010Gajardo","sequence":"first","affiliation":[{"name":"Hospital Dr. V\u00edctor R\u00edos Ru\u00edz Pediatric Intensive Care Unit Los \u00c1ngeles Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Aedo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Regional Dr. Guillermo Grant Benavente Pediatric Intensive Care Unit Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-6412","authenticated-orcid":false,"given":"Soledad","family":"Luarte\u2010Martinez","sequence":"additional","affiliation":[{"name":"Departamento de Kinesiolog\u00eda, Facultad de Medicina Universidad de Concepci\u00f3n Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-1254","authenticated-orcid":false,"given":"Pablo","family":"Cruces","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Vida Universidad Andres Bello Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-4410","authenticated-orcid":false,"given":"Juan","family":"Mayordomo\u2010Colunga","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias Pediatric Intensive Care Unit Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n 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