{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:25:05Z","timestamp":1786116305054,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Transcutaneous monitoring of CO\n                      <jats:sub>2<\/jats:sub>\n                      partial pressure (tcpCO\n                      <jats:sub>2<\/jats:sub>\n                      ) provides continuous information about the CO\n                      <jats:sub>2<\/jats:sub>\n                      partial pressure in the blood (pCO\n                      <jats:sub>2<\/jats:sub>\n                      ). However, the deviation of tcpCO\n                      <jats:sub>2<\/jats:sub>\n                      from pCO\n                      <jats:sub>2<\/jats:sub>\n                      is variable. Our aim was to assess whether this deviation depends on gestational age in the first postnatal week.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single\u2010center secondary data cohort study at a Tertiary Care NICU. 116 neonates undergoing tcpCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring were included. A linear mixed\u2010effects model was used to analyze the difference between tcpCO\n                      <jats:sub>2<\/jats:sub>\n                      and capillary pCO\n                      <jats:sub>2<\/jats:sub>\n                      (\u0394pCO\n                      <jats:sub>2<\/jats:sub>\n                      ) in the first postnatal week.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      926 simultaneous measurements were included. The evaluation of the linear mixed\u2010effects model revealed a significant effect of gestational age on \u0394pCO\n                      <jats:sub>2<\/jats:sub>\n                      . Median [interquartile 1; interquartile 3] \u0394pCO\n                      <jats:sub>2<\/jats:sub>\n                      was significantly higher for extremely preterm infants (&lt;\u200928 weeks) with 7.6 [2.4; 13.9] mmHg compared to 3.1 [\u22121.0; 6.4] mmHg for very preterm (28\u221231\u2009+\u20096 weeks), 0.6 [\u22124.6; 4.7] mmHg for late preterm (32\u221236\u2009+\u20096 weeks) and \u22120.5 [\u22124.8; 4.7] mmHg for term infants (\u2265\u200937 weeks). There were no significant differences in \u0394pCO\n                      <jats:sub>2<\/jats:sub>\n                      between patients born at 23 to 25 compared to 26 and 27 completed weeks of gestation. In multivariable analysis, gestational age, early\u2010onset bacterial infection and capillary pCO\n                      <jats:sub>2<\/jats:sub>\n                      were independently associated with \u0394pCO\n                      <jats:sub>2<\/jats:sub>\n                      , whereas birth weight was not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The gestational age has a significant directed effect on the accuracy of transcutaneous CO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring in preterm neonates and can\u2014together with other known influence factors\u2014be used to improve the non\u2010invasive pCO\n                      <jats:sub>2<\/jats:sub>\n                      estimation.\n                    <\/jats:p>\n                  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