{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:19:39Z","timestamp":1788239979483,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the association between the timing of maternal magnesium sulfate (MgSO\n                      <jats:sub>4<\/jats:sub>\n                      ) discontinuation before delivery and the risk of apnea of prematurity (AOP) in late\u2010preterm twin infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 161 twin pregnancies (322 infants) delivered between 34 0\/7 and 36 6\/7 weeks at Yamanashi Prefectural Central Hospital (2017\u20132025). Infants with major anomalies or intrauterine fetal demise were excluded. The primary exposure was the interval between MgSO\n                      <jats:sub>4<\/jats:sub>\n                      cessation and delivery, categorized as: no exposure, &lt;\u200912, 12\u201324, and \u2265\u200924\u2009h. Two multivariable logistic regression models were constructed.\n                      <jats:italic>Model 1<\/jats:italic>\n                      evaluated the association between any maternal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      exposure and AOP.\n                      <jats:italic>Model 2<\/jats:italic>\n                      further incorporated the timing of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      discontinuation as a categorical exposure, adjusting for gestational age, chorionicity, small\u2010for\u2010gestational\u2010age status, sex, and 1\u2010min Apgar score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 322 infants, 112 (34.8%) developed AOP. In Model 1, maternal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      exposure itself was not significantly associated with AOP. However, in Model 2, delivery within 12\u2009h after cessation of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      was independently associated with AOP (adjusted odds ratio, 7.44; 95% confidence interval, 1.48\u201337.4), whereas longer discontinuation intervals (12\u201324 or \u2265\u200924\u2009h) were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Among late\u2010preterm twin infants, maternal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      exposure itself was not independently associated with AOP; however, delivery soon after MgSO\n                      <jats:sub>4<\/jats:sub>\n                      discontinuation was associated with an increased risk of AOP. These findings support consideration of MgSO\n                      <jats:sub>4<\/jats:sub>\n                      discontinuation timing in perinatal risk assessment and neonatal respiratory monitoring and may help guide future studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71755","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:27:57Z","timestamp":1785137277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Timing of Magnesium Sulfate Cessation and Apnea of Prematurity in Late\u2010Preterm Twin Infants"],"prefix":"10.1002","volume":"61","author":[{"given":"Satoshi","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamanashi Prefectural Central Hospital Kofu Yamanashi 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