{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:55:00Z","timestamp":1791294900297,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital chylothorax is a rare pulmonary developmental disorder with high associated morbidity and mortality. A limited number of cases have been described, and clinical manifestations and outcomes vary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aims to delineate the neonatal and long\u2010term outcome of patients with congenital chylothorax by retrospective and prospective data collection at Ghent University Hospital in Belgium between 1992 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen patients with congenital chylothorax were included, seven of whom had a pathology\u2010confirmed diagnosis of congenital pulmonary lymphangiectasia. Of 16 patients with prenatal diagnosis, four underwent an intra\u2010uterine intervention. Thirteen patients were born prematurely. The most common comorbidities were hydrops (8\/18), pulmonary hypertension (3\/18), and reflux disease (6\/18). One patient was diagnosed with Noonan syndrome. The majority of patients (14\/18) required mechanical ventilation. Treatment included pleural drainage (15\/18), total parenteral nutrition (14\/18), medium\u2010chain triglyceride diet (11\/18), somatostatin (8\/18), and surgical intervention (3\/18), with a median hospital stay of 59 days. Three patients died during or after the neonatal period. Follow\u2010up ranged from 6 months to 30 years, with most patients reporting good general health but variable respiratory complaints. Five out of eight respiratory function tests showed mild abnormalities. Follow\u2010up chest CT showed persistent changes in all but two patients up to a maximum age of 16 years. Health\u2010related quality of life was similar to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Congenital chylothorax demonstrates a variable neonatal course. Long\u2010term outcomes are generally favorable in patients without comorbidities, although mild pulmonary function and chest CT abnormalities persist in the majority of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71820","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:35:36Z","timestamp":1788435336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Course and Long\u2010Term Outcome in Children With Congenital Chylothorax"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6169-9521","authenticated-orcid":false,"given":"N.","family":"Beullens","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Smets","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Lausnay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schelstraete","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Van daele","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Willekens","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Van Dorpe","sequence":"additional","affiliation":[{"name":"Department of Pathology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schaballie","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Infectious Diseases and Immunology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518217"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"108","article-title":"Congenital Chylothorax: Current Evidence\u2010Based Prenatal and Post\u2010Natal Diagnosis and Management","volume":"52","author":"De Angelis L. 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