{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:52:59Z","timestamp":1791294779246,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24CIII\/00013"],"award-info":[{"award-number":["PI24CIII\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Human respiratory syncytial virus (HRSV) is a major cause of respiratory disease. It is classified into two antigenic subgroups. While several authors have studied the potential link between HRSV infection and later development of recurrent wheezing (RW) or asthma, no previous studies have assessed the role of HRSV subtypes. The aim of this study was to assess the medium\u2010term respiratory morbidity in children and adolescents with prior severe bronchiolitis due to HRSV\u2010A or HRSV\u2010B infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From September 2023 to June 2025 an observational, prospective, cross\u2010sectional follow\u2010up study was conducted, including children and adolescents (5\u201318 years) with a history of hospital admission due to single HRSV infection. Patients underwent a structured questionnaire, measurement of exhaled nitric oxide, spirometry and skin prick testing for allergic sensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 185 patients were recruited (129 HRSV\u2010A, 56 HRSV\u2010B). No differences in the variables regarding hospital admission for bronchiolitis were detected. The prevalence of current asthma in both groups was similar (HRSV\u2010A 17.2% vs. 25.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.190). Patients with prior HRSV\u2010B bronchiolitis reported more severe respiratory symptoms, particularly speech\u2010limiting wheezing (HRSV\u2010A 1.5% vs. HRSV\u2010B: 8.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039, OR 2.62 (95% CI: 1.3\u20135.4)) and more frequent nocturnal dry cough not associated with infections (HRSV\u2010A: 7.7% vs. HRSV\u2010B 16.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044, OR: 1.78, (95% CI: 1.78\u20132.9)). Multivariate analysis revealed HRSV\u2010B prior bronchiolitis to be an independent risk factor for medical diagnoses of asthma and nocturnal cough.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Schoolchildren and adolescents with prior severe bronchiolitis due to HRSV\u2010B have poorer respiratory outcome compared to those with HRSV\u2010A, with more frequent intercrisis symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71837","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:31:16Z","timestamp":1789972276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asthma and Lung Function in School\u2010Aged Children After Severe RSV\u2010A and RSV\u2010B Bronchiolitis, Is There Any Difference?"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-0322","authenticated-orcid":false,"given":"Mar\u00eda Arroyas","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital (Legan\u00e9s) Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2940-579X","authenticated-orcid":false,"given":"Patricia Alonso","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital (Legan\u00e9s) Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe Tena","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital (Legan\u00e9s) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-3423","authenticated-orcid":false,"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"CIBER Infectious Diseases (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Spain"},{"name":"Pediatric Infectious and Tropical Diseases Department La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-4471","authenticated-orcid":false,"given":"Mar\u00eda","family":"Iglesias\u2010Caballero","sequence":"additional","affiliation":[{"name":"Reference and Research Laboratory for Respiratory Virus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mas","sequence":"additional","affiliation":[{"name":"Reference and Research Laboratory for Respiratory 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