{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:51Z","timestamp":1791294651537,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The prevalence and significance of bronchial hyperresponsiveness (BHR) in patients with non\u2010cystic fibrosis (CF) bronchiectasis remain unclear. The objective is to determine the prevalence of BHR, defined as a post\u2010bronchodilator forced expiratory volume in 1 s (FEV1) improvement &gt;\u200910%, in children with non\u2010CF bronchiectasis and to assess its association with clinical, functional, and radiological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This retrospective, observational monocentric study included children with non\u2010CF bronchiectasis followed\u2010up at an university center for rare pediatric respiratory diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Patients were eligible if they had performed spirometry with bronchodilator reversibility testing within 3 years of a diagnostic chest computed tomography (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes Measures<\/jats:title>\n                    <jats:p>Asthma symptoms, asthma exacerbations, asthma treatments, allergic markers, infectious exacerbations, causes of bronchiectasis, FEV1, FEV1\/forced vital capacity (FVC) ratio, reversibility, and mosaic attenuation on CT were compared between patients with and without BHR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 157 patients, 65 (male\/female sex ratio 0.71, mean age 10 years old, asthma symptoms in over 56% of patients, 67% treated with inhaled corticosteroids) met the inclusion criteria. BHR was present in 32.3% of cases. Patients with BHR had a significantly altered lung function (baseline Z\u2010score FEV1 \u22122.12 vs \u22120.87; FEV1\/FVC \u22122.28 vs \u22120.85). No significant association was found between BHR and clinical and radiological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BHR is not associated with clinical, radiological or therapeutic characteristics in pediatric non\u2010CF bronchiectasis, except a more severe airflow limitation. These findings highlight the importance of lung function assessment for non\u2010CF bronchiectasis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71839","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:35:09Z","timestamp":1790073309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bronchial Hyperresponsiveness in Pediatric Non\u2010Cystic Fibrosis Bronchiectasis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6971-8195","authenticated-orcid":false,"given":"Lisa","family":"Gerbeau","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Finet","sequence":"additional","affiliation":[{"name":"Unit of pediatric Pulmonary Function Testing La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bosdure","sequence":"additional","affiliation":[{"name":"Pediatric Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Papazian","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenza","family":"Tahiri","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisande","family":"Baravalle","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-7107","authenticated-orcid":false,"given":"Julie","family":"Mazenq","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"},{"name":"Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Dubus","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department University Hospital La Timone Enfants Marseille France"},{"name":"Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03952.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23380"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31554-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294921"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmi036"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000137510"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.151"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.03.72"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000492"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03891"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02718238"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.12.948"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.00961.x"},{"key":"e_1_2_10_16_1","unstructured":"Global Initiative for Asthma. 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