{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:58Z","timestamp":1791294658320,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Structural congenital pulmonary malformations encompass a heterogeneous group of developmental anomalies of the lung, pleura, and mediastinum that may cause significant neonatal morbidity and require specialized care. Population\u2010based healthcare utilization data from middle\u2010income countries remain scarce, limiting health system planning and comparative research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide, retrospective, population\u2010based study using Colombia's administrative healthcare registry (RIPS) to estimate the encounter\u2010based prevalence, sex\u2010specific distribution, age\u2010standardized rates, and temporal trends of structural congenital pulmonary malformations among children younger than 1 year between 2016 and 2024. Cases were identified using granular ICD\u201010 codes and analyzed at both subgroup and diagnosis\u2010specific levels. Crude and WHO age\u2010standardized prevalence rates were calculated per 100,000 population. Temporal trends were assessed using Poisson regression models with population offsets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 12,458 healthcare encounters related to structural congenital pulmonary malformations were identified during the study period, yielding a national crude encounter\u2010based prevalence of 111.3 per 100,000 children and a cumulative study\u2010period age\u2010standardized prevalence of 9.8 per 100,000 (2016\u20132024). Overall prevalence was higher in females than males (rate ratio 1.23, 95% CI 1.19\u20131.28). Temporal trend analyses demonstrated a modest but significant annual increase of approximately 2.2% (IRR 1.022; 95% CI 1.015\u20131.029;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A sensitivity analysis excluding 2019 confirmed the robustness of this trend (IRR 1.052; 95% CI 1.044\u20131.060;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first nationwide healthcare utilization\u2010based estimates of structural congenital pulmonary malformations in Colombian infants, revealing substantial diagnostic heterogeneity, sex\u2010specific patterns, and evolving temporal trends. These findings offer essential population\u2010based evidence to inform clinical practice, health service planning, and future epidemiological research. All estimates reflect healthcare encounter counts rather than unique individuals and should be interpreted as indicators of system\u2010level disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71841","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:57:51Z","timestamp":1789714671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population\u2010Based Epidemiology of Congenital Pulmonary Malformations in Early Infancy: A Nationwide Study From Colombia"],"prefix":"10.1002","volume":"61","author":[{"given":"Jefferson Antonio","family":"Buend\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Grupo de Investigaci\u00f3n en Farmacolog\u00eda y Toxicolog\u00eda Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Guerrero","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Grupo de Investigaci\u00f3n en Farmacolog\u00eda y Toxicolog\u00eda Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-8586(03)70004-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000549705"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2025.09.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-025-06251-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.15100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0254-2024"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1126"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.10.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.2.435"},{"key":"e_1_2_10_11_1","unstructured":"Ministerio de Salud de Colombia. SISPRO\u2014Sistema Integrado de Informaci\u00f3n de la Protecci\u00f3n Social [Internet]. Bogot\u00e1: Ministerio de Salud; 2025 [cited 2025 Jan].https:\/\/www.sispro.gov.co\/Pages\/Home.aspx."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.22379\/24224022426"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2020.07.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12300"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"175","article-title":"Analysis of Needs and Use of Mental Healthcare Services in Colombia","volume":"21","author":"Zamora\u2010Rondon D. 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Available from:https:\/\/www.minsalud.gov.co\/sites\/rid\/lists\/bibliotecadigital\/ride\/de\/dij\/resolucion-8430-de-1993.pdf."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.70309"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2018.022"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2350\/06-01-0023.1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-013-2668-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-011-2303-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2015.01.014"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4098-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.06.023"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.118"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12884"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.614864"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-024-01291-3"},{"key":"e_1_2_10_34_1","unstructured":"European Surveillance of Congenital Anomalies (EUROCAT). EUROCAT Prevalence Data: Congenital Pulmonary Airway Malformations and Respiratory Anomalies [Internet]. European Platform on Rare Disease Registration; 2023 [cited 2025].https:\/\/eu-rd-platform.jrc.ec.europa.eu\/eurocat\/eurocat-data\/prevalence."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:52:46Z","timestamp":1791291166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ppul.71841"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71841","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71841"}}