{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:59:35Z","timestamp":1790589575497,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Infant respiratory syncytial virus (RSV) prevention has moved from selective palivizumab prophylaxis toward broader protection through long\u2010acting monoclonal antibodies and maternal vaccination. We examined how this research area evolved and whether original studies address evidence needed for implementation at scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a bibliometric analysis and evidence\u2010gap mapping study of Web of Science Core Collection records from 1998 to 2025. The bibliometric corpus included 2004 publications; 1581 original articles underwent relevance screening and targeted audit, yielding 1227 studies for evidence\u2010gap mapping. Analyses compared 1998\u22122022 with 2023\u22122025. A random sample of 150 articles was used to validate relevance screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Publication output rose sharply after 2022, with 2023\u22122025 accounting for 35.0% of the bibliometric corpus. Earlier work centered on palivizumab, preterm infants, and hospitalization; recent studies increasingly addressed nirsevimab, maternal RSV vaccination, implementation, and vaccine candidates. Hospitalization outcomes, disease burden, monoclonal antibody strategies, and real\u2010world effectiveness were well represented, whereas coverage\/uptake, acceptance, equity, safety monitoring, economic evaluation, applicability to low\u2010 and middle\u2010income countries, and coordination between maternal vaccination and infant monoclonal antibodies were less common. Validation showed 86.7% agreement (Cohen's kappa\u2009=\u20090.52).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The literature has shifted toward broad infant RSV protection, but implementation\u2010relevant evidence remains uneven. Comparative and program\u2010level research is needed to determine how maternal vaccination and infant monoclonal antibody strategies can be implemented and coordinated across health systems while minimizing missed opportunities for protection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71853","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:45:59Z","timestamp":1790588759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Selective Prophylaxis to Broad Infant RSV Protection: A Bibliometric Analysis and Evidence Gap Map, 1998\u20132025"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-6714","authenticated-orcid":false,"given":"Zhongyuan","family":"Li","sequence":"first","affiliation":[{"name":"Senior Department of Pediatrics Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Children's Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the Fourth Medical Center of PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6191-9393","authenticated-orcid":false,"given":"Xiaohong","family":"Hu","sequence":"additional","affiliation":[{"name":"Senior Department of Pediatrics Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Children Younger Than 5 Years in 2019: A Systematic Analysis","volume":"399","author":"Li Y.","year":"2022","journal-title":"Lancet"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2015: a Systematic Review and Modelling Study","volume":"390","author":"Shi T.","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1093\/infdis\/jiac120","article-title":"Respiratory Syncytial Virus is the Leading Cause of United States Infant Hospitalizations, 2009\u20132019: A Study of the National (Nationwide) Inpatient Sample","volume":"226","author":"Suh M.","year":"2022","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1542\/peds.102.3.531","article-title":"Palivizumab, a Humanized Respiratory Syncytial Virus Monoclonal Antibody, Reduces Hospitalization From Respiratory Syncytial Virus Infection in High\u2010Risk Infants","volume":"102","author":"The IMpact\u2010RSV Study Group","year":"1998","journal-title":"Pediatrics"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1542\/peds.2014-1665","article-title":"Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection","volume":"134","author":"Brady M. 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J.","year":"2026","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_13_31_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S1473-3099(25)00742-X","article-title":"Impact of Universal Nirsevimab Prophylaxis in Infants on Hospital and Primary Care Outcomes Across Two Respiratory Syncytial Virus Seasons in Galicia, Spain (NIRSE\u2010GAL): A Population\u2010Based Prospective Observational Study","volume":"26","author":"Razzini J. 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W.","year":"2024","journal-title":"Pediatrics"},{"key":"e_1_2_13_35_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2024-066481","article-title":"Cost\u2010Effectiveness of Maternal Vaccination to Prevent Respiratory Syncytial Virus Illness","volume":"154","author":"Hutton D. 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Updated July 11 2025 accessed May 4 2026 https:\/\/www.cdc.gov\/vaccine-safety\/vaccines\/rsv.html."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:46:04Z","timestamp":1790588764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ppul.71853"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71853","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71853"}}