{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:48:57Z","timestamp":1792072137322,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Electrical impedance tomography (EIT) is a non\u2010invasive, effort\u2010independent imaging technique for measurement of regional lung ventilation and function that does not utilize ionizing radiation. There are limited data on the use of EIT to assess lung disease in people with CF (PwCF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional observational cohort study. Study participants performed EIT, multiple breath washout (MBW) and spirometry in a single session. We analyzed EIT results to calculate the global inhomogeneity index (GII) and regional ventilation delay at 40% of maximal inspiratory impedance (RVD40). We used pairwise Spearman correlations to compare EIT measurements with the lung clearance index (LCI) and percent predicted forced expiratory volume in 1\u2009s (FEV1pp). We generated receiver operator characteristic (ROC) curves to assess specificity and sensitivity for GII and RVD40 to predict an abnormal LCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      31 participants ranging in age from 6 to 65 years performed EIT and spirometry; 23 performed research\u2010quality MBW. The median GII and RVD40 were 39.1 and 5.52, respectively. The median LCI was 8.9. RVD40 correlated moderately with LCI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and negatively correlated with FEV1pp (\n                      <jats:italic>r\u2009<\/jats:italic>\n                      =\u2009\u22120.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). There was a weak positive correlation between GII and LCI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.21). GII demonstrated a significant negative correlation with FEV1pp (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We found that EIT measurements correlated with spirometry and MBW. RVD40 was more sensitive and specific for ventilation inhomogeneity as compared to GII. Our data suggest that EIT measurements made during tidal breathing could be a useful clinical test in the evaluation of CF lung disease, though further investigations are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71856","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:14:14Z","timestamp":1792070054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Cystic Fibrosis Lung Disease Using Electrical Impedance Tomography"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1874-303X","authenticated-orcid":false,"given":"Heather","family":"Boas","sequence":"first","affiliation":[{"name":"Section of Pediatric Pulmonology Dartmouth Health Children's Lebanon New Hampshire USA"},{"name":"Department of Pediatrics Geisel School of Medicine at Dartmouth Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bennett","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Faerber","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gari","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina E.","family":"Sailman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Pierdomenico","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-8465","authenticated-orcid":false,"given":"Natalie","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Respiratory Therapy Department Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dorgan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Penn Medicine Philadelphia Pennsylvania USA"},{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-283X","authenticated-orcid":false,"given":"Howard B.","family":"Panitch","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-0644","authenticated-orcid":false,"given":"Clement L.","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-32504-0","volume-title":"Handbook of Cystic Fibrosis","author":"Filbrun A. 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