{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:44Z","timestamp":1791125624085,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterise temporal dynamics, variance structure, determinants, and predictive relevance of oscillatory amplitude variability during high\u2010frequency oscillatory ventilation with volume guarantee (HFOV\u2010VG) in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010centre retrospective cohort study using minute\u2010level ventilator data collected during the first 72\u2009h of HFOV\u2010VG. Amplitude variability was quantified using standard deviation, coefficient of variation (CV), and root mean square of successive differences (RMSSD). Temporal patterns, variance decomposition, and determinants of variability were assessed using mixed\u2010effects modelling separating within\u2010 and between\u2010infant effects. Predictive performance for death before discharge or moderate\u2010to\u2010severe bronchopulmonary dysplasia was evaluated using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 237,790 measurements from 60 infants were analysed. Amplitude CV declined from 0.122 (0.072\u20130.160) at 0\u20136\u2009h to 0.063 (0.035\u20130.106) at 48\u201372\u2009h, while RMSSD decreased from 2.10 (1.22\u20132.69) to 1.13 (0.64\u20131.94). Variability was predominantly within\u2010infant (ICC 0.246\u20130.282), whereas mean amplitude, VThf\/kg, and frequency were predominantly between\u2010infant. Within\u2010infant increases in oscillatory frequency were associated with higher variability, whereas increases in mean airway pressure and time from HFOV initiation were associated with lower variability. The composite outcome occurred in 47\/60 infants. Early oscillatory amplitude variability demonstrated moderate discrimination (AUC 0.72, 95% CI 0.55\u20130.86), with an AUC of 0.82 (95% CI 0.66\u20130.95) when combined with oscillatory frequency and weight\u2010normalised DCO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oscillatory amplitude variability during HFOV\u2010VG reflects dynamic ventilator\u2013lung interactions. Its association with adverse respiratory outcome is hypothesis\u2010generating and requires validation in larger independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71859","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:34:48Z","timestamp":1791124488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Dynamics and Clinical Relevance of Oscillatory Amplitude Variability During High\u2010Frequency Oscillatory Ventilation With Volume Guarantee in Preterm Infants"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-717X","authenticated-orcid":false,"given":"Kamal","family":"Ali","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Department King Abdulaziz Medical City Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Centre Riyadh Saudi 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University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8421-8431","authenticated-orcid":false,"given":"Saif","family":"Alsaif","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Department King Abdulaziz Medical City Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Centre Riyadh Saudi Arabia"},{"name":"College of Medicine King Saud Bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Ali","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Department King Abdulaziz Medical City Riyadh Saudi Arabia"},{"name":"College of Medicine King Saud Bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre King's College Hospital London UK"},{"name":"Department of Women and Children's Health School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre King's College Hospital London UK"},{"name":"Department of Women and Children's Health School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London 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