{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:54:19Z","timestamp":1791125659961,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The association of\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (PsA) and\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      (HI) colonization with lung function in children with primary ciliary dyskinesia (PCD) remains insufficiently defined. We aimed to compare spirometric parameters between PsA\u2010 and HI\u2010colonized children and evaluate longitudinal changes before, at, and after chronic colonization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort included patients aged \u2265\u20095 years with definite or highly probable PCD and chronic PsA or HI colonization. Chronic colonization was defined using repeated sputum cultures over 12 months. Pulmonary function tests were analyzed 1 year before colonization, at colonization, and 1 year after colonization. FEV1, FVC, and FEF25\u201375 were reported as percent\u2010predicted values and GLI 2012 z\u2010scores. Individual pre\u2010to\u2010after\u2010colonization change scores and bronchiectasis subgroup analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 290 patients with PCD, 40 met inclusion criteria: 10 with PsA and 30 with HI colonization. PsA\u2010colonized patients were older at colonization than HI\u2010colonized patients (17 [12\u201323] vs. 11 [9\u201315] years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), and bronchiectasis was more frequent in the PsA group (100% vs. 60%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). PsA colonization was associated with lower lung function across several spirometric measures. Both groups showed significant within\u2010group declines in FEV1 and FEF25\u201375 over time. However, individual pre\u2010to\u2010after\u2010colonization changes in FEV1 and FEF25\u201375 z\u2010scores did not differ significantly between groups, including in the bronchiectasis subgroup analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PsA colonization was associated with lower lung function than HI colonization, but not with significantly greater longitudinal decline. These findings suggest that PsA may mark more advanced disease rather than independently accelerating functional loss. Larger prospective studies with non\u2010colonized comparators are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71861","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:38:56Z","timestamp":1791124736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Impact of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Versus\n                    <i>Haemophilus influenzae<\/i>\n                    Colonization on Lung Function Decline in Children With Primary Ciliary Dyskinesia"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1126-5965","authenticated-orcid":false,"given":"\u00d6mer Faruk","family":"\u0130pek","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-8401","authenticated-orcid":false,"given":"Nagehan Emiralio\u011flu","family":"Ordukaya","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-0056","authenticated-orcid":false,"given":"Asl\u0131 Kuzu","family":"Ku\u015fakl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy\/Immunology Ankara Bilkent City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-0770","authenticated-orcid":false,"given":"Meltem Akg\u00fcl","family":"Erdal","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-3319","authenticated-orcid":false,"given":"Havva \u0130pek","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-1981","authenticated-orcid":false,"given":"Ebru","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-5216","authenticated-orcid":false,"given":"U\u011fur","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fped.2017.00084","article-title":"Review: Quality of Life in Children With Non\u2010Cystic Fibrosis Bronchiectasis","volume":"5","author":"Nathan A. M.","year":"2017","journal-title":"Frontiers in Pediatrics"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1378\/chest.07-2812","article-title":"Structural and Functional Lung Disease in Primary Ciliary Dyskinesia","volume":"134","author":"Santamaria F.","year":"2008","journal-title":"Chest"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1093.e1","DOI":"10.1016\/j.cmi.2015.08.020","article-title":"A Longitudinal Study of Lung Bacterial Pathogens in Patients With Primary Ciliary Dyskinesia","volume":"21","author":"Alanin M. C.","year":"2015","journal-title":"Clinical Microbiology and Infection"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.rmed.2019.08.009","article-title":"A Retrospective Analysis of the Pathogens in the Airways of Patients With Primary Ciliary Dyskinesia","volume":"156","author":"Roden L.","year":"2019","journal-title":"Respiratory Medicine"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ppul.10127","article-title":"Pseudomonas Aeruginosa and Other Predictors of Mortality and Morbidity in Young Children With Cystic Fibrosis","volume":"34","author":"Emerson J.","year":"2002","journal-title":"Pediatric Pulmonology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01040-2018","article-title":"Lung Function in Patients With Primary Ciliary Dyskinesia: An IPCD Cohort Study","volume":"52","author":"Halbeisen F. S.","year":"2018","journal-title":"European Respiratory Journal"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01918-2021","article-title":"Lung Function From School Age to Adulthood in Primary Ciliary Dyskinesia","volume":"60","author":"Halbeisen F. S.","year":"2022","journal-title":"European Respiratory Journal"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01090-2016","article-title":"European Respiratory Society Guidelines for the Diagnosis of Primary Ciliary Dyskinesia","volume":"49","author":"Lucas J. S.","year":"2017","journal-title":"European Respiratory Journal"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement","volume":"200","author":"Graham B. L.","year":"2019","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"6","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi\u2010Ethnic Reference Values for Spirometry for the 3\u201395\u2010yr Age Range: The Global Lung Function 2012 Equations","volume":"40","author":"Quanjer P. H.","year":"2012","journal-title":"European Respiratory Society"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.rmed.2017.08.028","article-title":"Clinical Impact of Pseudomonas aeruginosa Colonization in Patients With Primary Ciliary Dyskinesia","volume":"131","author":"Cohen\u2010Cymberknoh M.","year":"2017","journal-title":"Respiratory Medicine"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ajmg.c.31968","article-title":"Primary Ciliary Dyskinesia in Volendam: Diagnostic and Phenotypic Features in Patients With a CCDC114 Mutation","volume":"190","author":"Kos R.","year":"2022","journal-title":"American Journal of Medical Genetics, Part C: Seminars in Medical Genetics"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00253-2024","article-title":"Associations Between Respiratory Pathogens and Lung Function in Primary Ciliary Dyskinesia: Cross\u2010Sectional Analysis From the PROVALF\u2010PCD Cohort","volume":"10","author":"Rubbo B.","year":"2024","journal-title":"ERJ Open Research"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00301-2021","article-title":"International BEAT\u2010PCD Consensus Statement for Infection Prevention and Control for Primary Ciliary Dyskinesia in Collaboration With ERN\u2010LUNG PCD Core Network and Patient Representatives","volume":"7","author":"Marthin J. K.","year":"2021","journal-title":"ERJ Open Research"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.71861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.71861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:38:58Z","timestamp":1791124738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.71861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ppul.71861"],"URL":"https:\/\/doi.org\/10.1002\/ppul.71861","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71861"}}