{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:49:05Z","timestamp":1791964145690,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021 SGR000396"],"award-info":[{"award-number":["2021 SGR000396"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Nirsevimab was approved in Europe in 2022 for respiratory syncytial virus (RSV) prevention. In October 2023, Catalonia (Spain) launched a universal immunization program for infants under 6 months during their first RSV season. This study aims to assess the characteristics of patients admitted with bronchiolitis following nirsevimab implementation and to compare the features of the immunized patients across two consecutive seasons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, observational, single\u2010center study included infants aged up to 12 months admitted for bronchiolitis between October 2023 and May 2025, comparing clinical and epidemiological data across two seasons (S1: October 2023\u2013May 2024; S2: October 2024\u2013May 2025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      574 patients were included (S1: 352; S2: 222), with a median age of 3.2 months (interquartile range [IQR]: 1.5\u20136.5). Most were previously healthy (437\/574, 76.1%) and immunized with nirsevimab (406\/574, 70.7%). RSV was detected in 215\/574 (37.5%) of cases. 159\/574 (27.7%) required Pediatric Intensive Care Unit (PICU) admission, and the median length of hospital stay was 5 days (IQR:3\u20138). In S2, immunization rates increased (S1:61.6% vs S2:85.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001) whereas RSV infections decreased (S1:41.2% vs S2: 31.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). Among immunized patients, S2 exhibited a higher proportion of healthy children (S1:65.0% vs S2:77.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), fewer PICU admissions (S1:33.2% vs S2:21.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and shorter hospital stays (S1: 6 [IQR:4\u20139.5] days vs S2: 5 [IQR:3\u20137.5] days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). Furthermore, in multivariable logistic regression analysis, admission during the second season remained independently associated with a lower risk of PICU admission (adjusted OR 0.587, 95% CI 0.368\u20130.936;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among hospitalized infants with bronchiolitis after nirsevimab implementation, immunized patients admitted during the second season showed more favorable clinical outcomes, including lower PICU utilization and shorter hospitalizations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.71873","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:34:01Z","timestamp":1791963241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Effects of Nirsevimab on Respiratory Syncytial Virus Bronchiolitis Outcomes: Insights From A Two\u2010Season Analysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8178-9650","authenticated-orcid":false,"given":"Marta","family":"Ag\u00fcera","sequence":"first","affiliation":[{"name":"Pediatrics Department Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"PhD Candidate, PhD Program in Medicine and Translational Research Universitat de Barcelona Barcelona 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Sevilla","sequence":"additional","affiliation":[{"name":"Pediatrics Department Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Pediatric Infectious Diseases and Microbiome Research Group Institut de Recerca Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Departament de Cirurgia i Especialitats Medicoquir\u00fargiques Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona Barcelona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-528X","authenticated-orcid":false,"given":"Juan\u2010Jos\u00e9","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pediatrics Department Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Pediatric Infectious Diseases and Microbiome Research Group Institut de Recerca Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Departament de Cirurgia i Especialitats Medicoquir\u00fargiques Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona Barcelona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-4425","authenticated-orcid":false,"given":"Iolanda","family":"Jordan","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases and Microbiome Research Group Institut de Recerca Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Departament de Cirurgia i Especialitats Medicoquir\u00fargiques Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona Barcelona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP) Madrid Spain"},{"name":"Pediatric Intensive Care Unit Department Hospital Sant Joan de D\u00e9u Barcelona 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L.","year":"2022","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1913556","article-title":"Single\u2010Dose Nirsevimab for Prevention of RSV in Preterm Infants","volume":"383","author":"Griffin M. 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L.","year":"2024","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"e_1_2_11_12_1","unstructured":"Ministerio de Sanidad de Espa\u00f1a \u201cRecomendaciones de Utilizaci\u00f3n de Nirsevimab Frente A Virus Respiratorio Sincitial Para la Temporada 2023\u20132024 \u201d [Internet].https:\/\/www.sanidad.gob.es."},{"issue":"8","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1473-3099(24)00215-9","article-title":"Effectiveness and Impact of Universal Prophylaxis With Nirsevimab in Infants Against Hospitalisation for Respiratory Syncytial Virus in Galicia, Spain: Initial Results of a Population\u2010Based Longitudinal Study","volume":"24","author":"Ares\u2010G\u00f3mez S.","year":"2024","journal-title":"Lancet Infectious Diseases"},{"issue":"4","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/vaccines12040383","article-title":"Effectiveness of Nirsevimab Immunoprophylaxis Administered at Birth to Prevent Infant Hospitalisation for Respiratory Syncytial Virus Infection: A Population\u2010Based Cohort Study","volume":"12","author":"Ezpeleta G.","year":"2024","journal-title":"Vaccines"},{"issue":"22","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.05.078","article-title":"Effectiveness of Nirsevimab Introduction Against Respiratory Syncytial Virus in the Valencian Community: A Preliminary Assessment","volume":"42","author":"Estrella\u2010Porter P.","year":"2024","journal-title":"Vaccine"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1441786","article-title":"The Effectiveness of Nirsevimab in Reducing the Burden of Disease Due to Respiratory Syncytial Virus (RSV) Infection over Time in the Madrid Region (Spain): A Prospective Population\u2010Based Cohort Study","volume":"12","author":"Barbas Del Buey J. 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