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Here, we introduce an <jats:italic>in vivo<\/jats:italic> sampling technique using capillary ultrafiltration (CUF) probes that are capable of continuously collecting pure <jats:italic>in vivo<\/jats:italic> secretome from tissue microenvironments. Great benefits of CUF probes when compared with other current sampling techniques have been acknowledged. CUF probes can be designed to fit various <jats:italic>in vivo<\/jats:italic> models and they are easily adapted to different protein\u2010detection systems including mass spectrometers. The future challenges and clinical advantages of CUF probe sampling are also highlighted in this review. Many prospective properties such as simple manipulation, dynamic sampling, pathogen clearance, online mass spectrometric coupling, and disease treatment and monitoring have made CUF probes attractive for clinical uses in the near future.<\/jats:p>","DOI":"10.1002\/prca.200700031","type":"journal-article","created":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T15:18:09Z","timestamp":1186759089000},"page":"953-962","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<b><i>In vivo<\/i><\/b> secretome sampling technology for proteomics"],"prefix":"10.1002","volume":"1","author":[{"given":"Chun\u2010Ming","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00318.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700540"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/09680519050110040801"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2006.01.002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568009043481542"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.2741\/1895"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2004.12.003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.034"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00046362","volume":"9","author":"D'Amore P. 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