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More than 200 gastric juice samples from healthy people, gastric ulcer patients, duodenal ulcer patients, and cancer patients were examined. There were clear pattern differences of mass spectra among samples from healthy people and patients with different gastric diseases. We found five peptides for gastric cancer diagnosis with high sensitivity and specificity. Sequences of these five peptides, including two pepsinogen fragments, leucine zipper protein fragment, albumin fragment, and \u03b1\u20101\u2010antitrypsin fragment, have been identified by mass spectrometric analysis and immuno\u2010deplete assay with antibodies.<\/jats:p>","DOI":"10.1002\/prca.200780066","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T17:16:45Z","timestamp":1200071805000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Observation of peptide differences between cancer and control in gastric juice"],"prefix":"10.1002","volume":"2","author":[{"given":"Wei\u2010Chao","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010I","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jung","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Hsuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70071-4"},{"key":"e_1_2_1_3_2","first-page":"1221","article-title":"Impact of bacterial eradication on the cell proliferation and p53 protein accumulation in Helicobacter pylori\u2010associated gastritis","volume":"20","author":"Hsu P. 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