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We conducted a cross\u2010sectional study in children undergoing elective cardiac catheterization to determine if there is a distinct preprocedural urinary proteomic profile in subjects who subsequently develop CIN. Of 90 patients enrolled, AKI due to CIN (defined as a 50% or greater increase in serum creatinine) occurred in 10 participants by the 24\u2005h postcontrast time point. Seven patients who did not develop AKI served as age and gender matched controls. SELDI\u2010TOF\u2010MS was performed using ProteinChips with different chromatographic surfaces. A 4480\u2005Da biomarker displayed significantly greater peak intensities on three chromatographic surfaces (<jats:italic>p<\/jats:italic>\u2005=\u20050.02\u20130.001) in control patients at time\u2005=\u20050 with an area under the curve (AUC) of 0.89\u20130.99. This biomarker was identified as the 41 amino acid (a.a.) variant of human beta\u2010defensin\u20101. Another biomarker of 4631\u2005Da was found to have a significantly greater peak intensity (<jats:italic>p<\/jats:italic>\u2005=\u20050.03) in AKI patients at time\u2005=\u20050, with an AUC of 0.84. Thus, the presence of a 4631\u2005Da peptide, as well as the absence of the 41 a.a. variant of human beta\u2010defensin\u20101 in the preprocedural urine, may prove to be useful biomarkers for the early prediction of CIN.<\/jats:p>","DOI":"10.1002\/prca.200780141","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T14:58:10Z","timestamp":1215701890000},"page":"1058-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Using proteomics to identify preprocedural risk factors for contrast induced nephropathy"],"prefix":"10.1002","volume":"2","author":[{"given":"Michael R.","family":"Bennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelima","family":"Ravipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert H.","family":"Beekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Rovner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00150-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.058"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2006.12.002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0218"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20964"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.068"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.3.329"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00336.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh868"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10684"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-002-1925-x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.19.2328"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/nips.01515.2003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.01.002"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000129114.92265.32"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086476"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0608-x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00352.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm170"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01733.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1861"},{"key":"e_1_2_1_23_2","first-page":"315","article-title":"Human beta\u2010defensin\u20101: A urinary peptide present in variant molecular forms and its putative functional implication","volume":"3","author":"Zucht H. 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