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Acute hepatitis C infection is usually asymptomatic and therefore rarely diagnosed. Nevertheless, HCV nucleic acid testing carried out on all blood donations detects donors who have resolved their HCV infection after seroconversion. Here we have used SELDI\u2010TOF\u2010MS technology to compare, at a proteomic level, plasma samples respectively from donors with HCV clearance, from donors with chronic HCV infection and from unexposed healthy donors (<jats:italic>n<\/jats:italic>\u2005=\u200515 <jats:italic>per<\/jats:italic> group). A candidate marker of about 9.4\u2005kDa was detected as differentially expressed in the three groups. After purification we identified by nanoLC\u2010Q\u2010TOF\u2010MS\/MS this candidate marker as Apolipoprotein C\u2010III (ApoC\u2010III). The identification was confirmed by western blot analysis. Levels of ApoC\u2010III were then determined in the 45 plasma samples by immunoturbidimetric assay. ApoC\u2010III was found to be higher in donors who had resolved their HCV infection than in donors with chronic infection, results which were consistent with SELDI\u2010TOF\u2010MS data. ApoC\u2010III is the first reported candidate biomarker in plasma associated with the spontaneous resolution of HCV infection.<\/jats:p>","DOI":"10.1002\/prca.200800020","type":"journal-article","created":{"date-parts":[[2008,5,7]],"date-time":"2008-05-07T07:18:08Z","timestamp":1210144688000},"page":"751-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of apolipoprotein C\u2010III as a potential plasmatic biomarker associated with the resolution of hepatitis C virus 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