{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:02Z","timestamp":1788871982792,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Campbell-Avery Charitable Trust"},{"name":"Dorr Family Charitable Trust"},{"name":"Lupus\/Juvenile Arthritis Research Group of Saint Louis"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Juvenile idiopathic arthritis reflects a group of clinically heterogeneous arthritides hallmarked by elevated concentrations of circulating immune complexes. In this study, the circulating immune complex proteome was examined to elucidate disease\u2010associated proteins that are overexpressed in patients with an aggressive, and at times destructive, disease phenotype. To solve this proteome, circulating immune complexes were isolated from the sera of patients with chronic, erosive or early\u2010onset, aggressive disease and from patients in medical remission or healthy controls subsequent to protein separation by 2\u2010DE. Thirty\u2010seven protein spots were overexpressed in the circulating immune complexes of the aggressive disease groups as compared to controls, 28 of which have been confidently identified to date. Proteolytic fragments of glyceraldehyde\u20103\u2010phosphate dehydrogenase, serotransferrin, and \u03b1\u20101\u2010antitrypsin have been identified among others. In total, these 28 putative disease\u2010associated proteins most definitely contribute to immune complex formation and likely have a significant role in disease etiology and pathogenesis. Moreover, these proteins represent markers of aggressive disease, which could aid in diagnosis and management strategies, and potential therapeutic targets to prevent or control disease outcome. This is the first in\u2010depth analysis of the circulating immune complex proteome in juvenile idiopathic arthritis.<\/jats:p>","DOI":"10.1002\/prca.200800073","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T23:22:18Z","timestamp":1247181738000},"page":"829-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease\u2010associated proteins"],"prefix":"10.1002","volume":"3","author":[{"given":"Jason M.","family":"Low","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine E.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ombrello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"983","volume-title":"Conn's Current Therapy 2009","author":"Moore T. 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