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Main late respiratory complications are chronic obstructive pulmonary disease, bronchiectasis, asthma, and bronchiolitis obliterans. The aim of the present study was to identify differentially expressed proteins in bronchoalveolar lavage (BAL) fluid of control healthy and sulfur mustard\u2010exposed lung disease patients. The BAL protein profile of ten healthy and 30 exposed patients with mild, moderate, and severe conditions (ten males in each group) were separated with 2\u2010D SDS\u2010PAGE and differentially expressed protein spots were successfully identified with MALDI TOF TOF MS. Among the differentially expressed proteins we observed a significant increase in vitamin D binding protein isoforms, haptoglobin isoforms, and fibrinogen especially in exposed moderate and severe lung diseases patients (<jats:italic>p<\/jats:italic>&lt;0.01). Moreover, compared with healthy controls, significant decreases was noted in calcyphosine, surfactant protein A, and transthyretin in these patients (<jats:italic>p<\/jats:italic>&lt;0.01). Apolipoprotein A1 was detected in all patients' BAL fluid but none of the healthy controls. Furthermore, S100 calcium\u2010binding protein A8 was only detected in BAL fluid of moderate and severe groups. These findings will be useful to improve current methods of monitoring and helps to identify new therapeutic targets for treatment of this complicated illness.<\/jats:p>","DOI":"10.1002\/prca.200900001","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T12:31:22Z","timestamp":1249561882000},"page":"1191-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Bronchoalveolar lavage fluid proteomic patterns of sulfur mustard\u2010exposed patients"],"prefix":"10.1002","volume":"3","author":[{"given":"Hossein","family":"Mehrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Ghanei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafar","family":"Aslani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Golmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.06.014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050372"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/01480549809007407"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9298259"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000094993.20914.d1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.3.734"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.5.598"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.01.016"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600303"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01511"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990601)20:7<1634::AID-ELPS1634>3.0.CO;2-J"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3670::AID-ELPS3670>3.0.CO;2-Z"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17407160"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00060902"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000701)21:13<2703::AID-ELPS2703>3.0.CO;2-W"},{"key":"e_1_2_6_17_2","unstructured":"American Thoracic Society Spirometric Classification (document on the internet)."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14b01.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.10.029"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305844"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2004.03.018"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00114-9"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2000.00790.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1476-5586(03)80015-5"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.6.1673"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200210)23:19<3434::AID-ELPS3434>3.0.CO;2-R"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90358-E"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00167.2006"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.4.549"},{"key":"e_1_2_6_31_2","first-page":"1","article-title":"Signaling molecules in sulfur mustard\u2010induced cutaneous injury","volume":"8","author":"Ruff A. 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