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Moreover, the range of quantitative ratios differing from the target value of 1.0 was statistically determined to be (0.6527, 1.5350) for the 99% confidence level in a fraction of plasma samples. The practicability of this method was further demonstrated in a pilot study on the differential proteomic analysis of cerebrospinal fluid, with the uncovering of 33 dysregulated proteins from different development stages.<\/jats:p><jats:p><jats:bold>Conclusions and clinical Relevance<\/jats:bold>: The outcome of the differential proteomic analysis of plasma protein and cerebrospinal fluid confirmed the whole strategy as a promising alternative for exploration of potential biomarker in complex clinical or biological samples.<\/jats:p>","DOI":"10.1002\/prca.200900065","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T14:25:01Z","timestamp":1268144701000},"page":"633-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A systematic N\u2010terminal peptide quantitative labeling strategy for differential proteomic 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