{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:05:36Z","timestamp":1761059136091},"reference-count":70,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:00:00Z","timestamp":1295222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Thalassemia Foundation, Kolkata"},{"name":"CSIR, India"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Red blood cell proteome has not been studied well until recently, as the large abundance of hemoglobin posed challenge to the detection of other cytosolic proteins in the linear dynamic range. However, in the last couple of years, due to emergence of various novel hemoglobin depletion strategies and more state\u2010of\u2010the\u2010art detection techniques, a number of works on erythrocyte proteome have appeared in the literature. As a result, we now have much deeper information about both the membrane as well as the cytosolic proteins of erythrocytes. In this review, we have discussed the role of red cell proteome on the two most well\u2010studied hemoglobin disorders, sickle cell disease and thalassemia, emphasizing on the differential expression of the redox regulator proteins and chaperones, in particular. We have also touched upon the importance of the association of the varying levels of hemoglobin variants, particularly HbE on the clinical manifestation of composite diseases like HbE\u03b2 thalassemia.<\/jats:p>","DOI":"10.1002\/prca.201000063","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T10:52:40Z","timestamp":1291373560000},"page":"98-108","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential expression of red cell proteins in hemoglobinopathy"],"prefix":"10.1002","volume":"5","author":[{"given":"Abhijit","family":"Chakrabarti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avik","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumanta","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sutapa","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchismita","family":"Halder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,17]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200701161"},{"key":"e_1_2_9_3_2","volume-title":"Plasma Membrane Dynamics and Organization","author":"Hoffman R.","year":"2000"},{"key":"e_1_2_9_4_2","first-page":"95","article-title":"Red blood cell deformability and hemolytic anemias","volume":"16","author":"Mohandas N.","year":"1979","journal-title":"Semin. Hematol."},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.49.030187.001141"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-9796(03)00019-6"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900831f"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.03.005"},{"key":"e_1_2_9_9_2","volume-title":"Blood: Principles and Practice of Hematology","author":"Walensky L. D.","year":"2003"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-007799"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.1869.1869"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.23.060194.004035"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(86)90112-2"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a128270"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(02)00003-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"crossref","first-page":"18964","DOI":"10.1016\/S0021-9258(18)55157-7","article-title":"Reconstitution of Ca (2+)\u2010dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein","volume":"266","author":"Moore R. B.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.07.002"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2548"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03393.x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-048728"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328329905c"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707818200"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.4190"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809076200"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00803"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.025"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.013"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-4-34"},{"key":"e_1_2_9_30_2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood.V53.6.1121.1121","article-title":"Red cell proteins. I. Two\u2010dimensional mapping of human erythrocyte lysate proteins","volume":"53","author":"Edwards J. J.","year":"1979","journal-title":"Blood"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501401183"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200209)2:9<1229::AID-PROT1229>3.0.CO;2-N"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01559-6"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.10.070"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780058"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.3181\/0805-S-149"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523001102"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2003.12.007"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01630.x-i2"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr070179d"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr049812a"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr060308a"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200700178"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M300132-MCP200"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr0497780"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr8001029"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800037-MCP200"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500147"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl817"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.3181\/0706-MR-156"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444318531.ch1"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222709"},{"key":"e_1_2_9_53_2","volume-title":"Bailli\u00e8re's Clinical Haematology; Sickle cell Disease and Thalassaemia","author":"Flint J.","year":"1998"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988787.ch3"},{"key":"e_1_2_9_55_2","first-page":"118","volume-title":"Hemoglobin: Structure, Function, Evolution and Pathology","author":"Dickerson R. E.","year":"1983"},{"key":"e_1_2_9_56_2","first-page":"215","volume-title":"Biochemistry","author":"Voet D.","year":"1995"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-847"},{"key":"e_1_2_9_58_2","first-page":"351","article-title":"Studies on the structural stability of haemoglobin E","volume":"58","author":"Yuthavong Y.","year":"1975","journal-title":"J. Med. Assoc. Thailand"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(80)91014-0"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470696705"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/288497a0"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198711000-00012"},{"key":"e_1_2_9_63_2","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1182\/blood.V88.7.2761.bloodjournal8872761","article-title":"Interaction of hemoglobin E and pyrimidine 5\u2032 nucleotidase deficiency","volume":"88","author":"Rees D. C.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/178792a0"},{"key":"e_1_2_9_65_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1182\/blood.V70.1.158.158","article-title":"Erythrocyte membrane skeleton abnormalities in severe beta\u2010thalassemia","volume":"70","author":"Shinar E.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_9_66_2","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1182\/blood.V79.6.1586.1586","article-title":"Globin\u2010chain specificity of oxidation\u2010induced changes in red blood cell membrane properties","volume":"79","author":"Schrier S. L.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_9_67_2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1182\/blood.V92.6.2141","article-title":"Is hemoglobin instability important in the interaction between hemoglobin E and beta thalassemia?","volume":"92","author":"Rees D. C.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900073"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06995.x"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-006-0026-2"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2009.11.003"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201000063","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201000063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201000063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:45:10Z","timestamp":1693482310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.201000063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,17]]},"references-count":70,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/prca.201000063"],"URL":"https:\/\/doi.org\/10.1002\/prca.201000063","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,17]]},"assertion":[{"value":"2010-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}