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Protein profiling was carried out using SELDI TOF MS SELDI\u2010TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> MS data analysis of sera did not give satisfactory statistical discrimination between the groups. Antibody\u2010based cytokine profiling revealed a number of cytokines with a change in their concentrations in both MF and psoriasis (IL\u20101Ra, IL\u20104, G\u2010CSF). The C\u2010X\u2010C motif chemokine 10 (IP\u201010, CXCL10) cytokine had a significantly increased concentration (<jats:italic>p<\/jats:italic>&lt;0,001) in samples from MF patients as compared with the other groups.<\/jats:p><jats:p><jats:bold>Conclusions and clinical relevance:<\/jats:bold> IP\u201010 may be considered as a promising biomarker for the differentiation between MF and other skin conditions.<\/jats:p>","DOI":"10.1002\/prca.201000165","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T18:47:54Z","timestamp":1308336474000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proteome and cytokine serum profiling to diagnose a mycosis fungoides"],"prefix":"10.1002","volume":"5","author":[{"given":"Sergei A.","family":"Moshkovskii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizaveta E.","family":"Sokolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina V.","family":"Brattseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Karpova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail A.","family":"Pyatnitskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna A.","family":"Kubanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander I.","family":"Archakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124696"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.01846.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.057"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12389114"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08761.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0746"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2033602100"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00922-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780095"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1805"},{"key":"e_1_2_7_12_2","first-page":"55","article-title":"Interleukins in the treatment of mycosis fungoides","volume":"143","author":"Gerami P.","year":"2008","journal-title":"G. 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