{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:52:42Z","timestamp":1760385162980},"reference-count":48,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose<\/jats:bold>: Electroconvulsive therapy (ECT) is a psychiatric treatment in which seizures are electrically induced in patients. Prior to treatment, patients are usually given short\u2010acting anaesthetics and muscle relaxants to avoid harm, e.g. musculoskeletal injury, during the convulsions. However, most molecular studies investigating the mechanism of action of ECT have not explored the potential effects of the pre\u2010treatment with anaesthetic and\/ or muscle relaxant.<\/jats:p><jats:p><jats:bold>Experimental design<\/jats:bold>: We have carried out a targeted proteome analysis using multiplex immunoassay platform of serum samples before and 10\u2009min after initiating the administration of the anaesthetic methohexital<jats:sup>\u00ae<\/jats:sup>and the muscle relaxant succinylcholine<jats:sup>\u00ae<\/jats:sup>to eight major depressive disorder patients undergoing ECT.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Twenty\u2010six out of 142 analysed molecules showed significant differences in abundance after the methohexital\/succinylcholine treatment. Importantly, eight of these molecules (fatty acid\u2010binding protein, insulin, interleukin (IL)1\u03b2, IL\u201010, IL\u20104, prolactin, S100 calcium\u2010binding protein B and tumor necrosis factor \u03b1) have been associated previously with effects of ECT.<\/jats:p><jats:p><jats:bold>Conclusions and clinical relevance<\/jats:bold>: These findings indicate that caution should be used when interpreting results in existing and future proteome\u2010based biomarkers studies on the effects of ECT in neuropsychiatric disease or the use of anaesthetic\/muscle relaxant in major surgical operations related to different therapeutic areas.<\/jats:p>","DOI":"10.1002\/prca.201100040","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T11:26:57Z","timestamp":1318850817000},"page":"644-649","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy"],"prefix":"10.1002","volume":"5","author":[{"given":"Viktoria","family":"Stelzhammer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Rothermundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Guest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Sondermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Martins\u2010de\u2010Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Rahmoune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Bahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"52","article-title":"Electroconvulsive therapy in treatment \u2013 resistant depression","volume":"12","author":"Mathew S. J.","year":"2005","journal-title":"Primary Psychiatry"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200106000-00003"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200112000-00003"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303253281204"},{"key":"e_1_2_4_6_2","doi-asserted-by":"crossref","unstructured":"UK ECT Review Groups Efficacy and safety of electroconvulsive therapy in depressive disorders: A systematic review and meta\u2010analysis.Lancet2003 361 799\u2013808.","DOI":"10.1016\/S0140-6736(03)12705-5"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00259-7"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30162-X"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00057"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.7.957"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0464"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_4_13_2","unstructured":"Team R. D. C. R: A language and environment for statistical computing.R Foundation for Statistical Computing.2009 Vienna Austria."},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.030361"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1986.tb10610.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.1.94"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0b013e3181571abb"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.11.035"},{"key":"e_1_2_4_19_2","first-page":"38","article-title":"Electroconvulsive therapy and prolactin release: relation to treatment response in melancholia","volume":"1","author":"Abrams R.","year":"1985","journal-title":"Convuls. Ther."},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1985.tb02611.x"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1982.tb00857.x"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.143.6.618"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622970701310989"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00222-9"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90895-3"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.144.6.643"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300135"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90004-6"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.3.394"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00202-X"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.yct.0000235925.37494.2c"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200312000-00002"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5377-03.2004"},{"key":"e_1_2_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.06.032"},{"key":"e_1_2_4_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-34-10841.2003"},{"key":"e_1_2_4_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995"},{"key":"e_1_2_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.80"},{"key":"e_1_2_4_38_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.33549\/physiolres.931255","article-title":"The relationship between glycemia, insulin and oxidative stress in hereditary hypertriglyceridemic rat","volume":"57","author":"Zourek M.","year":"2008","journal-title":"Physiol. Res."},{"key":"e_1_2_4_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.179218"},{"key":"e_1_2_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(04)79268-X"},{"key":"e_1_2_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.06.026"},{"key":"e_1_2_4_42_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460409.x"},{"key":"e_1_2_4_43_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2460\/ajvr.1994.55.03.379","article-title":"Early insulin response to an intravenous glucose tolerance test in horses","volume":"55","author":"Giraudet A.","year":"1994","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_4_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.8.1168"},{"key":"e_1_2_4_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1755-5"},{"key":"e_1_2_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.5.637"},{"key":"e_1_2_4_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14383.x"},{"key":"e_1_2_4_48_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4049\/jimmunol.134.1.157","article-title":"In vivo administration of purified human interleukin 2. I. Half\u2010life and immunologic effects of the Jurkat cell line\u2010derived interleukin 2","volume":"134","author":"Lotze M. T.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_4_49_2","first-page":"1180","article-title":"Pharmacokinetics of tumor necrosis factor alpha after intravenous administration in rats. Dose dependence and influence of tumor necrosis factor beta","volume":"39","author":"Zahn G.","year":"1989","journal-title":"Arzneimittelforschung"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201100040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201100040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T20:01:18Z","timestamp":1713038478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.201100040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":48,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/prca.201100040"],"URL":"https:\/\/doi.org\/10.1002\/prca.201100040","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}