{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:10:31Z","timestamp":1694754631761},"reference-count":69,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Coxiella burnetii<\/jats:italic>, the causative agent of <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> fever, is an intracellular bacterium and a potential weapon for bioterrorism. The widespread throughout the world, zoonosis is manifested clinically as a self\u2010limited febrile illness, as pneumonia (acute <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> fever) or as a chronic illness with endocarditis being its major complication. The recent <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> fever outbreak has driven the bacterium from a relatively cryptic, underappreciated, \u201cniche\u201d microorganism on the sideline of bacteriology, to one of possibly great impact on public health. Advances in the study of this microorganism proceeded slowly, primarily due to the, until recently, obligatory intracellular nature of the pathogen that in its virulent phase I must be manipulated under biosafety level\u20103 conditions. Proteomic studies, in particular, have generated a vast amount of information concerning several aspects of the bacterium such as virulence factors, detection\/diagnostic and immunogenic biomarkers, inter\u2010\/intraspecies variation, resistance to antibiotics, and secreted effector proteins with significant clinical impact. The phenomenon observed following the genomics era, that of generation and accumulation of huge amount of data that ultimately end up unexploited on several databases, begins to emerge in the proteomics field as well. This review will focus on the advances in the field of <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>. burnetii<\/jats:italic> proteomics through <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, attempting in parallel to utilize some of the proteomics findings by suggesting future directions for the improvement of <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> fever diagnosis and therapy.<\/jats:p>","DOI":"10.1002\/prca.201200096","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T07:25:37Z","timestamp":1355901937000},"page":"193-204","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The contribution of proteomics towards deciphering the enigma of <i><scp>C<\/scp>oxiella burnetii<\/i>"],"prefix":"10.1002","volume":"7","author":[{"given":"Iosif","family":"Vranakis","sequence":"first","affiliation":[{"name":"Regional Laboratory of Public Health of Crete  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Papadioti","sequence":"additional","affiliation":[{"name":"Division of Biochemistry Department of Chemistry University of Crete  Voutes Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis","family":"Tselentis","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Public Health of Crete  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Psaroulaki","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Public Health of Crete  Heraklion Greece"},{"name":"Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine Medical School University of Crete  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tsiotis","sequence":"additional","affiliation":[{"name":"Division of Biochemistry Department of Chemistry University of Crete  Voutes Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.518"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.07.016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002268"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812074106"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1355.063"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1128\/iai.55.5.1144-1150.1987","article-title":"Comparative virulence of intra\u2010 and interstrain lipopolysaccharide variants of \n                     Coxiella burnetii in the guinea pig model","volume":"55","author":"Moos A.","year":"1987","journal-title":"Infect. 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