{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:10:13Z","timestamp":1788894613033,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MMC\/VICC\/TSU Partnership PIs: Harold L. Moses and Samuel E. 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Therefore, the accurate diagnosis is of paramount importance in terms of medical care. The distinction between CC\/UC is made on the basis of clinical, radiologic, endoscopic, and pathologic interpretations but cannot be differentiated in up to 15% of inflammatory bowel disease patients. Correct management of this \u201cindeterminate colitis\u201d depends on the accuracy of future, and yet not known, destination diagnosis (CC\/UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental design<\/jats:title><jats:p>We have developed a proteomic methodology that has the potential to discriminate between UC\/CC. The histologic layers of 62 confirmed UC\/CC tissues were analyzed using MALDI\u2010MS for proteomic profiling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A Support Vector Machine algorithm consisting of 25 peaks was able to differentiate spectra from CC and UC with 76.9% spectral accuracy when using a leave\u201020%\u2010out cross\u2010validation. Application of the model to the entire dataset resulted in accurate classification of 19\/26 CC patients and 36\/36 UC patients when using a 2\/3 correct cutoff. A total of 114 peaks were found to have Wilcoxin rank sum <jats:italic>p<\/jats:italic>\u2010values of less than 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>This information may provide new avenues for the development of novel personalized therapeutic targets.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201200107","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T16:27:56Z","timestamp":1359995276000},"page":"541-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Erin H.","family":"Seeley","sequence":"first","affiliation":[{"name":"Department of Biochemistry Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Washington","sequence":"additional","affiliation":[{"name":"Department of Pathology Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vanderbilt University School of Medicine Nashville TN USA"},{"name":"Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine Nashville TN USA"},{"name":"Department of Pharmacology Medicine and Chemistry Vanderbilt University School of Medicine, Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amosy E.","family":"M'Koma","sequence":"additional","affiliation":[{"name":"Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine Nashville TN USA"},{"name":"Laboratory of Inflammatory Bowel Disease Research Department of Biochemistry and Cancer Biology Meharry Medical College School of Medicine Nashville TN USA"},{"name":"Department of General Surgery Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1137-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.057"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40819.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2006.050079"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01556.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/974540"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01699.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200108000-00003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200309000-00002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060433m"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20376"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20336"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2004.02.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.058560"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043406"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.051"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.056"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.38"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.070"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8523"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20933"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.6.905"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.211755"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21458"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.09.031"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.06.025"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904492"},{"key":"e_1_2_7_30_1","first-page":"27","article-title":"The final diagnosis in pouch patients for presumed ulcerative colitis may change to Crohn's disease: patients should be warned of the consequences","volume":"47","author":"Keighley M. 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