{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:12:28Z","timestamp":1768522348256,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Potential biomarkers have been investigated using proteomic studies in a variety of diseases. Some biomarkers have central roles in both diagnosis and monitoring of various disorders in clinical medicine, such as troponins, brain natriuretic peptide, and C\u2010reactive protein. Although several biomarkers have been suggested in human abdominal aortic aneurysm (AAA), reliable markers have been lacking. In this issue, Moxon et al. [<jats:italic>Proteomics Clin Appl<\/jats:italic>. 2014, <jats:italic>8<\/jats:italic>, 762\u2010772] undertook a broad and systematic proteomic approach toward identification of biomarkers in a commonly used AAA mouse model (AAA created by angiotensin\u2010II infusion). In this mouse model, apolipoprotein C1 and matrix metalloproteinase\u20109 were identified as novel biomarkers of stable AAA. This finding represents an important step forward, toward a clinically relevant role of biomarkers in AAA. This also encourages for further studies toward the identification of biomarkers (or their combinations) that can predict AAA progression and rupture, which would represent a major progress in AAA management and would establish an AAA biomarker as a much anticipated clinical tool.<\/jats:p>","DOI":"10.1002\/prca.201400051","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T12:02:40Z","timestamp":1403870560000},"page":"732-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biomarkers for AAA: Encouraging steps but clinical relevance still to be delivered"],"prefix":"10.1002","volume":"8","author":[{"given":"Nay Min","family":"Htun","sequence":"first","affiliation":[{"name":"Baker IDI Heart and Diabetes Institute  Melbourne Australia"},{"name":"Monash University  Melbourne Australia"},{"name":"The Alfred Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlheinz","family":"Peter","sequence":"additional","affiliation":[{"name":"Baker IDI Heart and Diabetes Institute  Melbourne Australia"},{"name":"Monash University  Melbourne Australia"},{"name":"The Alfred Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/epr.11.46"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-013-0238-7"},{"key":"e_1_2_4_4_1","article-title":"Urine proteome analysis reflects atherosclerotic disease in an ApoE\u2010\/\u2010 mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis","volume":"11","author":"Muhlen C.","year":"2012","journal-title":"Mol. 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