{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:28:34Z","timestamp":1789187314305,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"McNair Program"},{"DOI":"10.13039\/100007112","name":"SciFund Challenge 3","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007112","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the ASPIRE program"},{"DOI":"10.13039\/100000183","name":"U.S. Army Research Office","doi-asserted-by":"crossref","award":["W911NF-11-1-0304"],"award-info":[{"award-number":["W911NF-11-1-0304"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective and earlier diagnoses of CNS conditions. Proteomics and other omics MS\u2010based technologies are tools currently being utilized in much recent CNS research. Saliva is an interesting alternative biomaterial for the proteomic study of CNS disorders, with several advantages. Collection is noninvasive and saliva has many proteins. It is easier to collect than blood and can be collected by professionals without formal medical training. For psychiatric and neurological patients, supplying a saliva sample is less anxiety\u2010provoking than providing a blood sample, and is less embarrassing than producing a urine specimen. The use of saliva as a biomaterial has been researched for the diagnosis of and greater understanding of several CNS conditions, including neurodegenerative diseases, autism, and depression. Salivary biomarkers could be used to rule out nonpsychiatric conditions that are often mistaken for psychiatric\/neurological conditions, such as fibromyalgia, and potentially to assess cognitive ability in individuals with compromised brain function. As MS and omics technology advances, the sensitivity and utility of assessing CNS conditions using distal human biomaterials such as saliva is becoming increasingly possible.<\/jats:p>","DOI":"10.1002\/prca.201400153","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T17:00:53Z","timestamp":1422550853000},"page":"899-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Salivary proteomics and biomarkers in neurology and psychiatry"],"prefix":"10.1002","volume":"9","author":[{"given":"Kelly L.","family":"Wormwood","sequence":"first","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshanak","family":"Aslebagh","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Channaveerappa","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmalyn J","family":"Dupree","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Borland","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne P.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Psychology SUNY Plattsburgh  Plattsburgh NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costel C.","family":"Darie","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa G.","family":"Woods","sequence":"additional","affiliation":[{"name":"Biochemistry and Proteomics Group Department of Chemistry and Biomolecular Science Clarkson University  Potsdam NY USA"},{"name":"Center for Neurobehavioral Health SUNY Plattsburgh  Plattsburgh NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506709200"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000819"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1333-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200328"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300370"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2011-1083.ch013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109106931"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01543.x"},{"key":"e_1_2_5_10_1","first-page":"1","article-title":"The potential for proteomics in understanding neurodevelopmental disorders","volume":"5","author":"Wormwood K.","year":"2013","journal-title":"J. Proteomics Bioinform."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-06068-2_1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1046"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-013-9510-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1185-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08641.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.284091"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-06068-2_25"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.13"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050532"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200376"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9256-1-6"},{"key":"e_1_2_5_22_1","first-page":"125","article-title":"Proteomics of saliva: personal experience","volume":"30","author":"Scarano E.","year":"2010","journal-title":"Acta Otorhinolaryngol Ital."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2012.687361"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2010.01.004"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200800140"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.05.011"},{"key":"e_1_2_5_27_1","first-page":"227","article-title":"Variable cortisol circadian rhythms in children with autism and anticipatory stress","volume":"33","author":"Corbett B. A.","year":"2008","journal-title":"J. Psychiatry Neurosci."},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.137513"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-013-0472-0"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3138\/jvme.0513-073R1"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.153767"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.4.4.531"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.8.929"},{"key":"e_1_2_5_34_1","first-page":"109980041454649","article-title":"A genomic profile of the immune response to stroke with implications for stroke recovery","author":"Barr T. L.","year":"2014","journal-title":"Biol. Res. Nurs."},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr8004088"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-108"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr015"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01265.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00508.2005"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110731"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2876"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10048"},{"key":"e_1_2_5_43_1","first-page":"663","article-title":"Deafferentation\u2010induced increases in hippocampal insulin\u2010like growth factor\u20101 messenger RNA expression are severely attenuated in middle aged and aged rats","volume":"83","author":"Woods A. G.","year":"1998","journal-title":"Neuroscience"},{"key":"e_1_2_5_44_1","volume-title":"Centers for Disease Control and Prevention","author":"Blumberg S. J.","year":"2013"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800339"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.08.038"},{"key":"e_1_2_5_47_1","first-page":"1","article-title":"Use a saliva test to ID neurodegenerative disease","author":"Woods A. G.","year":"2014","journal-title":"Psychiatic Times"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.009"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00530-1"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_5_52_1","article-title":"Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic","author":"Duits F. H.","year":"2014","journal-title":"Alzheimers Dement."},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq008"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr015"},{"key":"e_1_2_5_55_1","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years \u2013 autism and developmental disabilities monitoring network, 11 sites, United States, 2010","volume":"28","author":"Wingate M.","year":"2014","journal-title":"MMWR Surveill. Summ."},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10083384"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.03.047"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e32834e843f"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300370"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/868576"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.19"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001943"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1450"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333412"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.04.007"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.020"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.050"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-113"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048835"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.59"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.05.005"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.9942"},{"key":"e_1_2_5_73_1","first-page":"337","article-title":"Loss of post\u2010translational modification sites in disease","author":"Li S.","year":"2010","journal-title":"Pac. Symp. Biocomput."},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-06068-2_27"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000060"},{"key":"e_1_2_5_76_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.31887\/DCNS.2014.16.1\/dmartins","article-title":"Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder","volume":"16","author":"Martins\u2010de\u2010Souza D.","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000819"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.09.016"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200504000-00008"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2273"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900076"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3346"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100042"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/2041-2223-3-19"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089366"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.5.532"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201400153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201400153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201400153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T22:58:47Z","timestamp":1694559527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.201400153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,30]]},"references-count":85,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/prca.201400153"],"URL":"https:\/\/doi.org\/10.1002\/prca.201400153","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,30]]},"assertion":[{"value":"2014-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}