{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:08:55Z","timestamp":1782263335752,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. 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We hypothesized that RA patients acquire inflammation\u2010induced modifications to the protein cargo of circulating lipoproteins that may be reversed by tocilizumab, an interleukin\u20106 receptor\u2010alpha inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental design<\/jats:title><jats:p>Size\u2010exclusion chromatography and reverse\u2010phase protein arrays using 29 antibodies against 26 proteins were applied at baseline and after tocilizumab treatment to analyze the distributions of apolipoproteins, enzymes, lipid transfer proteins, and other associated proteins in plasma lipoprotein fractions from 20 women with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 30% reduction in high\u2010density lipoprotein (HDL)\u2013associated serum amyloid A4 and complement C4 occurred with tocilizumab. Levels of C\u2010reactive protein, associated or comigrating with HDL and low\u2010density lipoprotein (LDL) peaks, were reduced on treatment by approximately 80% and 24%, respectively. Reductions in lipoprotein\u2010associated phospholipase A2, lipoprotein (a), and cholesteryl ester transfer protein in the LDL fraction suggest reductions in LDL\u2010associated proatherogenic factors. Elevations in very low\u2010density lipoprotein (VLDL) enriched with apolipoprotein E were equally observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>Tocilizumab treatment led to reductions in proinflammatory components and proatherogenic proteins associated with HDL. Whether changes in the proteome of VLDL, LDL, and HDL induced by anti\u2010inflammatory tocilizumab treatment in RA patients modify cardiovascular disease risk requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201500036","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T09:53:35Z","timestamp":1437386015000},"page":"183-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Remodeling of plasma lipoproteins in patients with rheumatoid arthritis: Interleukin\u20106 receptor\u2010alpha inhibition with tocilizumab"],"prefix":"10.1002","volume":"10","author":[{"given":"Janet S.","family":"Lee","sequence":"first","affiliation":[{"name":"Roche  Nutley NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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