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There is often a variable response to neoadjuvant treatment between individual patients and side effects are relatively common. There is an urgent need for novel biomarkers of upper gastrointestinal cancer, not only to improve screening and early diagnosis of the oesophageal and gastric cancers when treatment options are potentially more effective, but also to accurately guide therapy in more advanced disease. The development of predictive biomarkers will also help to more effectively identify those patients that will benefit from targeted therapies. Although many promising results have been derived from these studies there remains a lack of validated clinically applicable biomarkers available for translation into routine clinical use. This review will provide an overview of the recent proteomic research on upper gastrointestinal cancer protein biomarker identification and validation. The challenges faced in the development of validated, clinically acceptable and accurate protein biomarkers will also be discussed, along with possible areas of future progress.<\/jats:p>","DOI":"10.1002\/prca.201500079","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T10:04:41Z","timestamp":1447927481000},"page":"532-545","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Progress in the development of protein biomarkers of oesophageal and gastric cancers"],"prefix":"10.1002","volume":"10","author":[{"given":"Caroline","family":"Coghlin","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Craigavon Area Hospital  Portadown UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme I.","family":"Murray","sequence":"additional","affiliation":[{"name":"Pathology, Division of Applied Medicine, School of Medicine and Dentistry University of Aberdeen  Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.01.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400082"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2727"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.264"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4586"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.09.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.02.008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2014.919856"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28963"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2014-2492"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.04.025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23110"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.05.008"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1024"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2012.0133"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.179"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.6.16833"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.15"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.02.012"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24194"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1366"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4199"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0679"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201400379"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31823699f2"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2726"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100709b"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq366"},{"key":"e_1_2_12_31_1","first-page":"4873","article-title":"Comparing mass screening techniques for gastric cancer in Japan","volume":"12","author":"Tashiro A.","year":"2006","journal-title":"World J. 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