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In addition, antipsychotic treatment can produce often undesired severe side effects in the patients and addressing these remains a large unmet clinical need. One of the reasons for the low effectiveness of these drugs is the limited knowledge about the molecular mechanisms of schizophrenia, which impairs the development of new and more effective treatments. Recently, proteomic studies of clinical and preclinical samples have identified changes in the levels of specific proteins in response to antipsychotic treatment, which have converged on molecular pathways such as cell communication and signaling, inflammation and cellular growth, and maintenance. The findings of these studies are summarized and discussed in this review and we suggest that this provides validation of proteomics as a useful tool for mining drug mechanisms of action and potentially for pinpointing novel molecular targets that may enable development of more effective medications.<\/jats:p>","DOI":"10.1002\/prca.201500109","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T15:42:29Z","timestamp":1450366949000},"page":"442-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Employing proteomics to unravel the molecular effects of antipsychotics and their role in schizophrenia"],"prefix":"10.1002","volume":"10","author":[{"given":"Juliana S.","family":"Cassoli","sequence":"first","affiliation":[{"name":"Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Guest","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline G.","family":"Santana","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Martins\u2010de\u2010Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"},{"name":"UNICAMP Neurobiology Center  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60995-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110430"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004060070002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.07.025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.9.907"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/epr.11.70"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462000000500002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31887\/DCNS.2010.12.3\/ajablensky","article-title":"The diagnostic concept of schizophrenia: its history, evolution, and future prospects","volume":"12","author":"Jablensky A.","year":"2010","journal-title":"Dialogues Clin. 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