{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:29:48Z","timestamp":1791300588534,"version":"4.1.0"},"reference-count":251,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Mass spectrometry\u2010based assays are increasingly important in clinical laboratory medicine and nowadays are already commonly used in several areas of routine diagnostics. These include therapeutic drug monitoring, toxicology, endocrinology, pediatrics, and microbiology. Accordingly, some of the most common analyses are therapeutic drug monitoring of immunosuppressants, vitamin D, steroids, newborn screening, and bacterial identification. However, MS\u2010based quantification of peptides and proteins for routine diagnostic use is rather rare up to now despite excellent analytical specificity and good sensitivity.<\/jats:p><jats:p>Here, we want to give an overview over current fit\u2010for\u2010purpose assays for MS\u2010based protein quantification. Advantages as well as challenges of this approach will be discussed with focus on feasibility for routine diagnostic use.<\/jats:p>","DOI":"10.1002\/prca.201500116","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T10:11:42Z","timestamp":1452075102000},"page":"323-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Clinical applications of MS\u2010based protein quantification"],"prefix":"10.1002","volume":"10","author":[{"given":"Bassel","family":"Sabbagh","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry Medical Faculty Mannheim of the University of Heidelberg University Hospital Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonani","family":"Mindt","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry Medical Faculty Mannheim of the University of Heidelberg University Hospital Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Neumaier","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry Medical Faculty Mannheim of the University of Heidelberg University Hospital Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Findeisen","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry Medical Faculty Mannheim of the University of Heidelberg University Hospital Mannheim  Mannheim Germany"},{"name":"MVZ Labor Dr. Limbach und Kollegen  Heidelberg Germany"},{"name":"Working Group Proteomics of the German United Society for Clinical Chemistry and Laboratory Medicine e.V. (DGKL)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/1841648b0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.045"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2004.01.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.06.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.11.225"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.11.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.126706"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002535"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201500046"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700023-MCP200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1255\/ejms.1256"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.01.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500331-MCP200"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.12.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900217"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100387"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.12.15"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.09.030"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100436"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400178v"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1546"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.173856"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.047050"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100821m"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300014s"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.054585"},{"key":"e_1_2_11_28_1","first-page":"91","article-title":"LC\/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens","volume":"8","author":"Thumfart J. O.","year":"2015","journal-title":"J. Proteomics Bioinform."},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134427"},{"key":"e_1_2_11_30_1","first-page":"1","article-title":"Use of anticoagulants in diagnostic laboratory investigations and Stability of blood, plasma and serum samples","author":"Guder W. G.","year":"2002","journal-title":"WHO\/DIL\/LAB\/99.1 Rev.2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2015.03.003"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060550h"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800396c"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.047308"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401245"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.050708"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900517"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21694"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R112.024869"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201100039"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700354-MCP200"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800382"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201200037"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr070339l"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01187.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300282"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700132-MCP200"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2011.08.009"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.4.2.175"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.03.025"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204366109"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400121"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00109"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac2029216"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300652v"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400115"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv091"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800401m"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/128_2012_413"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac060613f"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O112.020131"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400136"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800538n"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.034660"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1895"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1770"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.138420"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.11.005"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1108-913"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.56"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj138"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr049882h"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq054"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr5006636"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1584"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900010h"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900713u"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3072"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.03.006"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S16-S9"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu305"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2009.07.035"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.5023"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.01055.x"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-163"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu151"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700057"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.4172\/jpb.1000149"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.11.281"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.11.004"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.08.018"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.196"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth774"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.008235"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr9011969"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-12-3"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr201092v"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.7.1041"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2010.01.024"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-10-20"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.10.008"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400173"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100571"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.05.004"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800032-MCP200"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.03.026"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr5011179"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000736"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300893w"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2763"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.013854"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr500834z"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr4011712"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-013-0824-5"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr5010955"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac901597h"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.062505"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.107052"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.016"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.10.1676"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.06.006"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.199794"},{"key":"e_1_2_11_124_1","first-page":"105","article-title":"The Joint Committee for Traceability in Laboratory Medicine (JCTLM): a global approach to promote the standardisation of clinical laboratory test results","volume":"28","author":"Armbruster D.","year":"2007","journal-title":"Clin. Biochem. Rev."},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0722"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr401060x"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6883"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.08.003"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/164846"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac402326v"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.111989"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.109652"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.195594"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1967"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.163006"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.142"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.199786"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506120308999000"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-493-3_21"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05646.x"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.078956"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.134643"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.137323"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr614"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.026625"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.088393"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20154"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000112"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-6271-5"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300300"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-4897-3"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-7838-0"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-4565-z"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.03.005"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr025537l"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.03.058"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.094144"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800238-MCP200"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.01.035"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.06.007"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200800197"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.141"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5033066"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900269s"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.12.023"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900233"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.09.007"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201100082"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334537"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.1890"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-1048"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr050475v"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0611"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr0703627"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-121471"},{"key":"e_1_2_11_176_1","first-page":"356","article-title":"High\u2010performance liquid chromatography coupled with tandem mass spectrometry for the detection of amyloid Beta peptide related with Alzheimer's disease","volume":"16","author":"Du C.","year":"2005","journal-title":"J. Biomol. Tech."},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.10.163"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132489"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.39"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.018861"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1251"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2014.31"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200600771"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.022442"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400117"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201100062"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400014"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200700284"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.100"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201200123"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurx.2006.05.002"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000060"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300103"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700397-MCP200"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.133462"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-56"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.2984"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0580"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2012.02674.x"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.225185"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400137"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214521161"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000096"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.01.040"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0574"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0723"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.036095"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.11.022"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1309\/V50H4FRVVWX12C79"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-014-9696-2"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-10-13"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1517\/17530059.1.2.153"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000130"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214557678"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20145728"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017213"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780174"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1235"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.08.027"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.10.018"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.09.005"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400985k"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201400382"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300109"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2015.04.016"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2011.03.004"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3130"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000046"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400178"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr5010828"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000035"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201500020"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1817-x"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000599"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800540-MCP200"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1899"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300034"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12540"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013699108"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr1011087"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1900"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2467"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2015.04.020"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.05.003"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200600999"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000115"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003989"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-10-16"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700476-MCP200"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr201117w"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M900140-MCP200"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100568"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201500116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201500116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201500116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T02:44:15Z","timestamp":1694486655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.201500116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":251,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/prca.201500116"],"URL":"https:\/\/doi.org\/10.1002\/prca.201500116","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]},"assertion":[{"value":"2015-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}