{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:23:00Z","timestamp":1783347780725,"version":"3.54.6"},"reference-count":123,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TR124"],"award-info":[{"award-number":["SFB\/TR124"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["InfectControl 2020"],"award-info":[{"award-number":["InfectControl 2020"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Filamentous fungi of the genus <jats:italic>Aspergillus<\/jats:italic> play significant roles as pathogens causing superficial and invasive infections as well as allergic reactions in humans. Particularly invasive mycoses caused by <jats:italic>Aspergillus<\/jats:italic> species are characterized by high mortality rates due to difficult diagnosis and insufficient antifungal therapy. The application of immunoproteomic approaches has a great potential to identify new targets for the diagnosis, therapy, and vaccine development of diseases caused by <jats:italic>Aspergillus<\/jats:italic> species. Serological proteome analyses (SERPA) that combine 2D electrophoresis with Western blotting are still one of the most popular techniques for the identification of antigenic proteins. However, recently a growing number of approaches have been developed to identify proteins, which either provoke an antibody response or which represent targets of T\u2010cell immunity in patients with allergy or fungal infections. Here, we review advances in the studies of immune responses against pathogenic <jats:italic>Aspergilli<\/jats:italic> as well as the current status of diagnosis and immunotherapy of <jats:italic>Aspergillus<\/jats:italic> infections.<\/jats:p>","DOI":"10.1002\/prca.201600053","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T09:27:12Z","timestamp":1466155632000},"page":"910-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immunoproteomics of <i>Aspergillus<\/i> for the development of biomarkers and immunotherapies"],"prefix":"10.1002","volume":"10","author":[{"given":"Olaf","family":"Kniemeyer","sequence":"first","affiliation":[{"name":"Department of Molecular and Applied Microbiology Leibniz Institute for Natural Product Research and Infection Biology \u2010 Hans Kn\u00f6ll Institute (HKI)  Jena Germany"},{"name":"Institute of Microbiology Friedrich Schiller University  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