{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:53:14Z","timestamp":1790189594921,"version":"4.1.0"},"reference-count":117,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Psychobiology in Israel"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Psychiatric conditions, in many cases, arise from social interactions necessary for optimal mental functioning. Dominance and submissiveness are two opposite poles of behavior, stemming from processes of social interactions between members inside one group or species. Extreme dominance and submissiveness expressions in humans is accompanied by mental impairments, including mania and depression. Here, taking advantage of animals bred selectively for traits of dominance and submissiveness, we assess protein expression profiles in dominant and submissive mice in the context of social interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental design<\/jats:title><jats:p>Proteins extracted from hippocampi of na\u00efve and social interaction subjected dominant, submissive and wild type mice (15 mice per each group) are quantified using label\u2010free quantitative LC\/MS\/MS analysis. Complexity of social interaction\u2010related protein expression is resolved by factor analysis and enriched with GO and protein\u2010protein interaction functional network analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1146 proteins exhibiting expression changes in the wild type mice, as well as dominant and submissive mice are enriched in protein datasets responsible for: 1) socially triggered dominance (90 proteins), 2) inherent submissiveness (75 proteins), 3) socially triggered submissiveness (117 proteins), and 4) social interaction triggered protein expression changes, related to resilience\/adaptation to stress (69 proteins). Among the most enriched categories, extensive changes are found in proteins related to presynaptic release, ion channel regulation, circadian rhythm, MAPK, ErbB and NF\u2010kB pathways.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data extracted from this first extensive proteomic study of a social interaction paradigm may facilitate decoding of molecular mechanisms responsible for pathogenesis of psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201700089","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T17:22:43Z","timestamp":1499275363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of social interactions on hippocampal protein expression in animal dominant and submissive model of behavioral disorders"],"prefix":"10.1002","volume":"11","author":[{"given":"Natalia","family":"Borovok","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elimelech","family":"Nesher","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Reichenstein","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Tikhonova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishai","family":"Levin","sequence":"additional","affiliation":[{"name":"de Botton Institute for Protein Profiling The Nancy &amp; Stephen Grand Israel National Center for Personalized Medicine Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Pinhasov","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-1443","authenticated-orcid":false,"given":"Izhak","family":"Michaelevski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"},{"name":"Department of Biochemistry and Molecular Biology Tel Aviv University  Tel\u2010Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"489","article-title":"Diagnosis and treatment of bipolar disorders in adults: a review of the evidence on pharmacologic treatments","volume":"7","author":"Jann M. 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