{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:16:19Z","timestamp":1775481379328,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["91614177"],"award-info":[{"award-number":["91614177"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Intrauterine growth restriction, a major cause of fetal morbidity and mortality, is defined as a condition in which the fetus does not reach its genetically given growth potential. Screening for intrauterine growth restriction biomarkers in the mother's blood would be of great help for optimal pregnancy management and timing of delivery as well as for identifying fetuses requiring further surveillance during their infancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>A multiplexing serological assay based on liquid chromatography\u2013multiple\u2010reaction\u2010monitoring mass spectrometry is applied for distinguishing serum samples of pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assessment of concentrations of apolipoproteins and of proteins that belong to the lipid transport system is performed with maternal serum samples, consuming only 10\u00a0\u03bcL of serum per multiplex assay from each patient. Of all investigated proteins the serum concentrations of apolipoprotein B100 shows the greatest power for discriminating intrauterine growth restriction from control samples, reaching areas under curves above 0.85 in receiver\u2010operator\u2010characteristics analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate the potential of liquid chromatography\u2010multiple\u2010reaction\u2010monitoring mass spectrometry to become of clinical importance in the future for intrauterine growth restriction risk assessment based on maternal apolipoprotein B100 serum levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201800017","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T07:55:11Z","timestamp":1530258911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal Apolipoprotein B100 Serum Levels are Diminished in Pregnancies with Intrauterine Growth Restriction and Differentiate from Controls"],"prefix":"10.1002","volume":"12","author":[{"given":"Manja","family":"W\u00f6lter","sequence":"first","affiliation":[{"name":"Proteome Center Rostock Medical Faculty and Natural Science Faculty University of Rostock  Schillingallee 69 18057 Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Okai","sequence":"additional","affiliation":[{"name":"Proteome Center Rostock Medical Faculty and Natural Science Faculty University of Rostock  Schillingallee 69 18057 Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek S.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Victoria\u2010Genome British Columbia Proteomics Center Vancouver Island Technology Park University of Victoria  4464 Markham St #3101 BC V8Z 7X8 Victoria Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Ru\u00df","sequence":"additional","affiliation":[{"name":"Proteome Center Rostock Medical Faculty and Natural Science Faculty University of Rostock  Schillingallee 69 18057 Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical Faculty RWTH Aachen University  Pauwelsstra\u03b2e 30 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical Faculty RWTH Aachen University  Pauwelsstra\u03b2e 30 52074 Aachen Germany"},{"name":"Department of Obstetrics and Gynecology Medical Faculty University of Schleswig\u2010Holstein Campus Kiel  Arnold\u2010Heller\u2010Stra\u00dfe 3 24105 Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-6512","authenticated-orcid":false,"given":"Christoph H.","family":"Borchers","sequence":"additional","affiliation":[{"name":"University of Victoria\u2010Genome British Columbia Proteomics Center Vancouver Island Technology Park University of Victoria  4464 Markham St #3101 BC V8Z 7X8 Victoria Canada"},{"name":"Department of Biochemistry and Microbiology University of Victoria  Petch Building Room 207, 3800 Finnerty Rd. 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