{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:02:37Z","timestamp":1760889757547,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/13\/5\/30177"],"award-info":[{"award-number":["RE\/13\/5\/30177"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["603288"],"award-info":[{"award-number":["603288"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Progeria\u2010like syndromes offer a unique insight into aging. Here the case of a boy affected with mandibuloacral dysplasia and compound heterozygous mutations in <jats:italic>ZMPSTE24<\/jats:italic> is presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Capillary electrophoresis\u2010mass spectroscopy is used for proteome analysis to analyze peptides previously found to be differentially regulated in chronic kidney disease (273 peptides defining the CKD273 classifier), coronary artery disease (238 peptides defining the CAD238 classifier), and aging (116 peptides defining the AGE116 classifier).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No evidence of renal disease is identified. Although the boy has no overt cardiovascular disease other than a raised carotid intima media thickness relative to his age, a proteomic classifier for the diagnosis of coronary artery disease is mildly raised. The biological age based on the proteomic AGE116 classifier is 24 years compared to the chronological ages of 5 and 10 years. In contrast, a control group of healthy children has a significantly lower (<jats:italic>p<\/jats:italic> &lt; 0.0001) calculated mean age of 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary proteomic analysis is effective in confirming advanced biological age and to identify early evidence of renal or cardiovascular damage. This case highlights the value of proteomic approaches in aging research and may represent a method for non\u2010invasive monitoring of the effects of early aging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201800135","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T08:39:13Z","timestamp":1544690353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous <i>ZMPSTE24<\/i> Mutation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-1684","authenticated-orcid":false,"given":"Angela K","family":"Lucas\u2010Herald","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow G12 8TA UK"},{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Z\u00fcrbig","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Rotenburger Str. 20 30659 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avril","family":"Mason","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Kinning","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Queen Elizabeth University Hospital  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona E","family":"Brown","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow G12 8TA 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