{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:19:38Z","timestamp":1769282378456,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Periodontal diseases, the most common chronic inflammatory diseases in humans, do not only affect tooth\u2010supporting tissues but also other body parts by contributing to the development of life\u2010threatening conditions. Since currently available diagnostic methods in periodontics lack the ability to identify patients at high risk for periodontal disease progression, development of innovative, non\u2010invasive, rapid detection methods for diagnosing periodontal diseases is needed. This study aims to assess the potential of infrared attenuated total reflection (IR\u2010ATR) spectroscopy to detect differences in composition of saliva supernatant in non\u2010periodontitis individuals (control) and patients with generalized aggressive periodontitis (G\u2010AgP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>IR\u2010ATR is performed with a wavelength interval from 1230 to 1180 cm<jats:sup>\u22121<\/jats:sup>, analyzed with a simple subtraction in absorbance data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten samples show in the analysis of variance of the two data sets a true difference (99.8%). A principal component analysis (PCA) is able to discriminate between G\u2010AgP and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>This study demonstrates for the first time that IR\u2010ATR spectroscopy is a promising tool for the analysis of saliva supernatant for the diagnosis of periodontitis, and potentially other periodontal conditions. IR\u2010ATR spectroscopy holds the potential to be miniaturized and utilized as a non\u2010invasive screening test.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201900092","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T14:37:11Z","timestamp":1580395031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Salivary Fingerprinting of Periodontal Disease by Infrared\u2010ATR Spectroscopy"],"prefix":"10.1002","volume":"14","author":[{"given":"Kerstin Meta\u2010Catherina","family":"Beyer\u2010Hans","sequence":"first","affiliation":[{"name":"Laser Spectroscopy and Sensing Lab Institute for Quantum Electronics  ETH Zurich Zurich 8093 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Werner","family":"Sigrist","sequence":"additional","affiliation":[{"name":"Laser Spectroscopy and Sensing Lab Institute for Quantum Electronics  ETH Zurich Zurich 8093 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Silbereisen","sequence":"additional","affiliation":[{"name":"Section of Periodontology and Dental Prevention Division of Oral Diseases Department of Dental Medicine Karolinska Institutet  Huddinge 14152 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli Ozgen","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Adnan Menderes University  Aydin 09100 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnur","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Egg University  Izmir 35100 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Section of Periodontology and Dental Prevention Division of Oral Diseases Department of Dental Medicine Karolinska Institutet  Huddinge 14152 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.106"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30038-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290108.x"},{"key":"e_1_2_5_4_1","first-page":"381","volume":"26","author":"Greenstein G.","year":"2005","journal-title":"Compend. Contin. Educ. Dent. Jamesburg NJ"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510380414"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080480"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.000718"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511420434"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.68"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201500518"},{"key":"e_1_2_5_11_1","first-page":"61","volume":"224","author":"Mitsakakis K.","year":"2016","journal-title":"Stud. Health Technol. Inform."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1917844"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00193a004"},{"key":"e_1_2_5_14_1","first-page":"899","volume":"44","author":"Heise H. M.","year":"1998","journal-title":"Cell. Mol. Biol. Noisy\u2013Gd. Fr."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13250"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082416"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1366\/0003702053641360"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(99)00004-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8AN00919H"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.346"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100632"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01243.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01361.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512470691"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12061"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00315.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0323"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46417-0"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080296"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0412"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2019.07.006"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3an36654e"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900701512555"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2003615"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00288.x"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprca.201900092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201900092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prca.201900092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.201900092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:03:08Z","timestamp":1693342988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.201900092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/prca.201900092"],"URL":"https:\/\/doi.org\/10.1002\/prca.201900092","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"2019-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900092"}}