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The tumorigenesis of CVS and SVS have not been fully elucidated, and this study is designed to identify differentially expressed proteins involved in the tumorigenesis of CVS and SVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>Tandem mass tag\u2010based proteomics is used to determine the protein expression profiles from CVS and SVS tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 differentially expressed proteins are identified between CVS and SVS, with 6 being upregulated and 24 being downregulated. Bioinformatics analyses are performed according to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. These results indicate that two selected proteins (<jats:italic>COL1A1<\/jats:italic> and <jats:italic>COL1A2<\/jats:italic>) are potential biomarkers for distinguishing CVS and SVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Differentially expressed proteins linked to CVS and SVS are identified, and these proteins might provide potential biomarkers for human VS diagnosis. Furthermore, the present study supports the notion that decreased collagen might be the reason for bleeding associated with CVS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201900112","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T07:34:40Z","timestamp":1583912080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Differential Protein Expression between Cystic and Solid Vestibular Schwannoma Using Tandem Mass Tag\u2010Based Quantitative Proteomic Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-7745","authenticated-orcid":false,"given":"Jianhui","family":"Xu","sequence":"first","affiliation":[{"name":"ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Key Laboratory of Hearing Medicine of NHFPC  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