{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:28:32Z","timestamp":1789687712721,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The \u201cShrunken pore syndrome\u201d (SPS) is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFR<jats:sub>cystatinC<\/jats:sub>\/eGFR<jats:sub>creatinine<\/jats:sub>\u2010ratio. Studies have demonstrated a high risk for cardiovascular morbidity and mortality for patients with SPS. In this discovery study, we explored associations between SPS and proteins implicated in cardiovascular disease and inflammation in patients with heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>Plasma samples from 300 individuals in HARVEST\u2010Malm\u00f6 trial hospitalized for the diagnosis of heart failure (mean age 74.9 \u00b1 11.5 years; 30.0% female), were analyzed with a proximity extension assay consisting of 92 proteins. A Bonferroni\u2010corrected <jats:italic>p<\/jats:italic>\u2010value of 0.05\/92\u00a0=\u00a05.4\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup> was considered significant in the initial age and sex\u2010adjusted analyses. Presence of SPS was defined as eGFR<jats:sub>cystatinC<\/jats:sub> \u2264 60% of eGFR<jats:sub>creatinine<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SPS presented with significant associations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a05.4\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>) in age and sex\u2010adjusted logistic regressions with elevated levels of six proteins; scavenger receptor cysteine rich type 1 protein M130, tumor necrosis factor receptor 1, tumor necrosis factor receptor 2, osteoprotegerin, interleukin\u20102 receptor subunit alpha, and tyrosine\u2010protein kinase receptor UFO. All proteins remained associated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) with SPS after multivariate adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>In heart failure patients, SPS was associated with proteins linked to atherosclerosis and cell proliferation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.202000089","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T05:04:07Z","timestamp":1615179847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients"],"prefix":"10.1002","volume":"15","author":[{"given":"Liana","family":"Xhakollari","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Department of Nephrology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-0158","authenticated-orcid":false,"given":"Amra","family":"Jujic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Skane University Hospital, Department of Cardiology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Molvin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Skane University Hospital, Department of Cardiology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Skane University Hospital, Department of Cardiology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmus","family":"Bachus","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margret","family":"Leosdottir","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Skane University Hospital, Department of Cardiology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Grubb","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-8418","authenticated-orcid":false,"given":"Anders","family":"Christensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Department of Nephrology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"},{"name":"Skane University Hospital, Department of Cardiology Lund University  Malm\u00f6 Sweden"},{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Hypertension in Africa Research Team North\u2010West University Potchefstroom  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214234"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043161"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2015.1025427"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.634023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2015.1099724"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438755"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2016.1149882"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1576101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2020.06.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2016.1223338"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2020.1759139"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.220707"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.09.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12223"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0741"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510902946992"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365511003642535"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655102753611771"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510701203488"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655101753218346"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701318133"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2012.727019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321169"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.08.064"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04222.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.160"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02170.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.154724"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93025"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix082"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050511"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305289"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb02937.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3841com"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.155143"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq172"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2310\/6650.2007.06013"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0080161"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.202000089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prca.202000089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.202000089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:41:43Z","timestamp":1693352503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.202000089"}},"subtitle":["Shrunken pore syndrome and proteomic associations"],"short-title":[],"issued":{"date-parts":[[2021,3,20]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/prca.202000089"],"URL":"https:\/\/doi.org\/10.1002\/prca.202000089","archive":["Portico"],"relation":{},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,20]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000089"}}