{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:34:07Z","timestamp":1784010847129,"version":"3.55.0"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K08GM134220"],"award-info":[{"award-number":["K08GM134220"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM122846"],"award-info":[{"award-number":["R01GM122846"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM145596"],"award-info":[{"award-number":["R35GM145596"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD016262"],"award-info":[{"award-number":["S10OD016262"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Training Grant"],"award-info":[{"award-number":["Training Grant"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG060179"],"award-info":[{"award-number":["R03AG060179"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Delirium presents a significant healthcare burden. It complicates post\u2010operative care in up to 50% of cardiac surgical patients with worse outcomes, longer hospital stays and higher cost of care. Moreover, the nature of delirium following cardiac surgery with cardiopulmonary bypass (CPB) remains unclear, the underlying pathobiology is poorly understood, status quo diagnostic methods are subjective, and diagnostic biomarkers are currently lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify diagnostic biomarkers of delirium and for insights into possible neuronal pathomechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Design<\/jats:title>\n                    <jats:p>Comparative proteomic analyses were performed on plasma samples from a nested matched cohort of patients who underwent cardiac surgery. Validation by targeted proteomics was performed in an independent set of samples. Biomarkers were assessed for biological functions and diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010seven percent of subjects demonstrated delirium. Of 3803 proteins identified from patient samples by multiplexed quantitative proteomics, 16 were identified as signatures of exposure to CPB, and 11 biomarkers distinguished delirium cases from non\u2010cases (AuROC\u00a0=\u00a093%). Notable among these biomarkers are C\u2010reactive protein, serum amyloid A\u20101 and cathepsin\u2010B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The interplay of systemic and central inflammatory markers sheds new light on delirium pathogenesis. This work suggests that accurate identification of cases may be achievable using panels of biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/prca.202200066","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T02:45:45Z","timestamp":1672022745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post\u2010operative delirium"],"prefix":"10.1002","volume":"17","author":[{"given":"Kwame","family":"Wiredu","sequence":"first","affiliation":[{"name":"Department of Molecular and Systems Biology Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"},{"name":"Department of Anesthesia Critical Care and Pain Medicine Mass General Hospital  Boston Massachusetts USA"},{"name":"Department of Anaesthesia Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care and Pain Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Naseem","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care and Pain Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L.","family":"Brauer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arminja N.","family":"Kettenbach","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"},{"name":"Dartmouth Cancer Center Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildreth R.","family":"Frost","sequence":"additional","affiliation":[{"name":"Dartmouth Cancer Center Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"},{"name":"Department of Biomedical Data Science Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Shaefi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Anesthesia Critical Care and Pain Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-5051","authenticated-orcid":false,"given":"Scott A.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"},{"name":"Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"},{"name":"Dartmouth Cancer Center Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033\u20103182(97)71420\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.20.2467"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000098033.94737.84"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000061"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60688\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.12.074"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.04.071"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102083440601"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.10.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.05.076"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112923"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2010.02762.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.09.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1708046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.05.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010015\u20102610\u20103"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.06.07.22276115"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4823"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2018.04.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.03.2098"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265\u2010018\u20109835\u20108"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igy023.2115"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.027"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","unstructured":"Vasunilashorn S. Dillon S. Chan N. Fong T. Joseph M. Tripp B. \u2026Elias J.(2021).Proteome\u2010Wide Analysis using SOMAscan Identifies and Validates Chitinase\u20103\u2010Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.Journals of Gerontology. Series A Biological Sciences and Medical Sciences.","DOI":"10.1093\/gerona\/glaa326"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","unstructured":"Rhee J. Kuznetsov A. Mckay T. Lyons M. Houstis N. Mekkonen J. Ethridge B. Ibala R. Hahm E. Gitlin J. Guseh J. S Kitchen R. Rosenzweig A. &Shaefi S. Flaczyk A. Qu J. Akeju O.(2021).Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium 13 699763.https:\/\/doi.org\/10.3389\/fnagi.2021.699763","DOI":"10.3389\/fnagi.2021.699763"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"McKay T. Rhee J. Colon K. Adelsberger K. Turco I. Mueller A. Qu J. &Akeju O.(2021).Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.Journal of Cardiothoracic and Vascular Anesthesia.","DOI":"10.1053\/j.jvca.2021.05.002"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"Han Y. Chen W. Song Y. Yuan Y. Li Z. Zhou Y. Liu T. Han D. Mi X. Li M. Wang G. Zhong L. Zhou J. &Guo X.(2020).Proteomic Analysis of Preoperative CSF Reveals Risk Biomarkers of Postoperative Delirium 11 170.https:\/\/doi.org\/10.3389\/fpsyt.2020.00170","DOI":"10.3389\/fpsyt.2020.00170"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20102337\u20101"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003650"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2005.53221.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12144"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010113\u201012\u2010941"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010017\u20100407\u20106"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200439"},{"issue":"1","key":"e_1_2_9_36_1","first-page":"57","article-title":"Python: A programming language for software integration and development","volume":"17","author":"Sanner M. F.","year":"1999","journal-title":"Journal of Molecular Graphics and Modelling"},{"key":"e_1_2_9_37_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Core Team R.","year":"2013"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02386"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109868.2005.00503.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1963.10500845"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq054"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832254100"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.196"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20156297"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.07.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195659"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.06.042"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","unstructured":"Jiang L. &Lei G.(2022).Albumin\/fibrinogen ratio an independent risk factor for postoperative delirium after total joint arthroplasty.Geriatrics & Gerontology International.","DOI":"10.1111\/ggi.14381"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432\u20101327.1999.00657.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010018\u20100047\u20100"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103940(97)00196\u20101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012529\u20107"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101205\u20106"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.09.003"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11248\u2010019\u201000166\u2010x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135352"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.78920"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.027"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010101023"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00248"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2020.140428"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102011\u2010110101"},{"key":"e_1_2_9_64_1","volume-title":"Handbook of Proteolytic Enzymes","author":"Barrett A. J.","year":"2012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.016"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2011.06692.x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7357"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142080"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76.s2.05"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2011.03883.x"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010009\u20101341\u2010x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S163248"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1951.4.2.53"},{"issue":"7","key":"e_1_2_9_74_1","first-page":"771","article-title":"Incidence and risk factors for delirium and other adverse outcomes in older adults after coronary artery bypass graft surgery","volume":"15","author":"Rolfson D. B.","year":"1999","journal-title":"The Canadian journal of cardiology"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010017\u20100938\u20105"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_43_20"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017430701302490"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)01281-9"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr901079v"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201600175"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003283"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bb95"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv083"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14243"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9110308"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050553"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.146142"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1235"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780174"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M900254-MCP200"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr070233q"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300187"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_9_94_1","first-page":"2482","volume-title":"aptamers they trust: Caveats of the SOMAscan biomarker discovery platform from SomaLogic","author":"Joshi A.","year":"2018"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0303\u2010255"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500426102"}],"container-title":["PROTEOMICS \u2013 Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.202200066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prca.202200066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prca.202200066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T02:48:04Z","timestamp":1692326884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prca.202200066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/prca.202200066"],"URL":"https:\/\/doi.org\/10.1002\/prca.202200066","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.08.22276153","asserted-by":"object"}]},"ISSN":["1862-8346","1862-8354"],"issn-type":[{"value":"1862-8346","type":"print"},{"value":"1862-8354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"assertion":[{"value":"2022-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200066"}}