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Total urinary hydroxyproline excretion served as marker for bone resorption (BR) but was replaced by \u03b2\u2010CrossLaps (CTX), a C\u2010terminal collagen \u03b1\u20101(I) chain (COL1A1) telopeptide. We investigated the low\u2010molecular\u2010weight urinary proteome for peptides associated with changes in bone metabolism after kidney transplantation. Methods: Clinical and laboratory data including serum levels of CTX in 96 KTR from two nephrology centers were correlated with signal intensities of urinary peptides identified by capillary electrophoresis mass spectrometry. Results: Eighty\u2010two urinary peptides were significantly correlated with serum CTX levels. COL1A1 was the predominant peptide source. Oral bisphosphonates were administered for decreased bone density in an independent group of 11 KTR and their effect was evaluated on the aforementioned peptides. Study of the peptides cleavage sites revealed a signature of Cathepsin K and MMP9. Seventeen of these peptides were significantly associated with bisphosphonate treatment, all showing a marked reduction in their excretion levels compared to baseline. Discussion: This study provides strong evidence for the presence of collagen peptides in the urine of KTR that are associated with BR and that are sensitive to bisphosphonate treatment. Their assessment might become a valuable tool to monitor bone status in KTR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.202200118","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T07:24:52Z","timestamp":1687850692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urinary collagen peptides: Source of markers for bone metabolic processes in kidney transplant recipients"],"prefix":"10.1002","volume":"17","author":[{"given":"David","family":"Marx","sequence":"first","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Nouvel H\u00f4pital Civil  Strasbourg France"},{"name":"INSERM UMR\u2010S1109 FMTS  Strasbourg France"},{"name":"Hospital of S\u00e9lestat  S\u00e9lestat France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[{"name":"INSERM U1151  Paris France"},{"name":"Department of Nephrology and Kidney Transplantation Necker Hospital, AP\u2010HP  Paris France"},{"name":"Medical Faculty Paris University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Caillard","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Nouvel H\u00f4pital Civil  Strasbourg France"},{"name":"INSERM UMR\u2010S1109 FMTS  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Moulin","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Nouvel H\u00f4pital Civil  Strasbourg France"},{"name":"INSERM UMR\u2010S1109 FMTS  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Kochman","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Nouvel H\u00f4pital Civil  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Mischak","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Latosinska","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Bienaim\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1151  Paris France"},{"name":"Department of Nephrology and Kidney Transplantation Necker Hospital, AP\u2010HP  Paris France"},{"name":"Department of Physiology Necker Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Pri\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1151  Paris France"},{"name":"Department of Nephrology and Kidney Transplantation Necker Hospital, AP\u2010HP  Paris France"},{"name":"Department of Physiology Necker Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; 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