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Glycerophospholipid decreased concentration in AF can be a consequence of intracellular transport of lipids to the placental or fetal tissues under development. The increased intracellular concentration of lipids can lead to mitochondrial dysfunction and neurodegeneration caused by lipid droplet accumulation. Furthermore, the dysregulation of amino acid metabolism was a molecular fingerprint of microcephalic phenotypes, specifically serine, and proline metabolisms. Both amino acid deficiencies were related to neurodegenerative disorders, intrauterine growth retardation, and placental abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This study enhances our understanding of the development of CZS pathology and sheds light on dysregulated pathways that could be relevant for future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.202300008","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T07:26:48Z","timestamp":1686986808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amniotic fluid metabolomics identifies impairment of glycerophospholipid and amino acid metabolism during congenital Zika syndrome development"],"prefix":"10.1002","volume":"18","author":[{"given":"Patricia","family":"Sosa\u2010Acosta","sequence":"first","affiliation":[{"name":"Proteomics Unit, Department of Biochemistry Institute of Chemistry Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"Laboratory of Proteomics, LADETEC, Institute of Chemistry Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"Precision Medicine Research Center Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisa P. 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