{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:14:35Z","timestamp":1772118875904,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK125187"],"award-info":[{"award-number":["R01 DK125187"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Elevated levels of inflammation associated with human immunodeficiency virus (HIV) infection are one of the primary causes for the burden of age\u2010related diseases among people with HIV (PWH). Circulating proteins can be used to investigate pathways to inflammation among PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental design<\/jats:title>\n                    <jats:p>\n                      We profiled 73 inflammation\u2010related protein markers and assessed their associations with chronological age, sex, and CD4\n                      <jats:sup>+<\/jats:sup>\n                      cell count among 87 black South African PWH before antiretroviral therapy (ART).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 1, 1, and 14 inflammatory proteins significantly associated with sex, CD4\n                      <jats:sup>+<\/jats:sup>\n                      cell count, and age respectively. Twelve out of 14 age\u2010associated proteins have been reported to be associated with age in the general population, and 4 have previously shown significant associations with age for PWH. Furthermore, many of the age\u2010associated proteins such as CST5, CCL23, SLAMF1, MMP\u20101, MCP\u20101, and CDCP1 have been linked to chronic diseases such as cardiovascular disease and neurocognitive decline in the general population. We also found a synergistic interaction between male and older age accounting for excessive expression of CST5.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical relevance<\/jats:title>\n                    <jats:p>We found that advanced age may lead to the elevation of multiple inflammatory proteins among PWH. We also demonstrated the potential utility of proteomics for evaluating and characterizing the inflammatory status of PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/prca.202300015","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:38:26Z","timestamp":1694021906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of inflammation\u2010related proteome with demographic and clinical characteristics of people with HIV in South Africa"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-0225","authenticated-orcid":false,"given":"Junyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaysingh","family":"Brijkumar","sequence":"additional","affiliation":[{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnathan A.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics and School of Medicine Rollins School of Public Health Emory University  Atlanta Georgia USA"},{"name":"School of Health and Social Care Lincoln International Institute for Rural Health University of Lincoln  Lincoln UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E.","family":"Ord\u00f3\u00f1ez","sequence":"additional","affiliation":[{"name":"Hubert Department of Global Health Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew R.","family":"Dudgeon","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Sunpath","sequence":"additional","affiliation":[{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvan","family":"Pillay","sequence":"additional","affiliation":[{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"},{"name":"Adrenergy Research Innovations  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravi","family":"Moodley","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences National Health Laboratory Service University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Kuritzkes","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Y. S.","family":"Moosa","sequence":"additional","affiliation":[{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tooru","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Public Health Institute  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent C.","family":"Marconi","sequence":"additional","affiliation":[{"name":"Hubert Department of Global Health Rollins School of Public Health  Atlanta Georgia USA"},{"name":"Division of Infectious Diseases Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Atlanta Veterans Affairs Health Care System  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan V.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Global HIV & AIDS statistics \u2013 Fact sheet. 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