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Trunk control is a prerequisite for walking; however, knowledge regarding whether core stability and balance training influence walking is limited. This study aimed to investigate the immediate and long\u2010term effects of a group\u2010based, individualized, comprehensive core stability and balance intervention (GroupCoreDIST) compared with those of standard care on walking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This assessor\u2010blinded, prospective randomized controlled trial included 80 participants (Expanded Disability Status Scale scores 1\u20136.5) randomly allocated to GroupCoreDIST, conducted in groups of three for 60\u00a0min three times per week for 6\u00a0weeks (18 sessions) or standard care (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040\/40). One participant attended no posttests, leaving 79 subjects for intention\u2010to\u2010treat analysis. The assessments were performed at baseline and at Weeks 7, 18, and 30. Outcomes included the 2\u2010min walk test (2MWT), 10\u2010m walk test\u2010preferred\/fast\/slow speed (10MWT), Multiple Sclerosis Walking Scale\u201012 (MSWS\u201012), Patient Global Impression of Change\u2010walking (PGIC\u2010walking), Rivermead Visual Gait Assessment (RVGA), and ActiGraphsWgt3X\u2010BT activity monitors (ActiGraph). The statistical analyses included repeated\u2010measures mixed models performed in IBM SPSS Version 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant between\u2010group differences in the outcome measurements at baseline. The mean differences between groups were significant at all follow\u2010up time points in favour of GroupCoreDIST for the 2MWT, 16.7\u00a0m at 7\u00a0weeks (95% CI [8.15, 25.25], 15.08\u00a0m at 18\u00a0weeks (95% CI [6.39, 23.77]) and 16.38\u00a0m at 30\u00a0weeks (95% CI [7.65, 25.12]; and the PGIC\u2010walking, 0.89 points at 7\u00a0weeks (95% CI [1.34, 0.45]), 0.97 points at 18\u00a0weeks (95% CI [1.42, 0.52]), and 0.93 points at 30\u00a0weeks (95% CI [1.39, 0.48]; all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a0.001). The 10MWT\u2010fast speed and the MSWS\u201012 showed significant between\u2010group differences at 7 and 18\u00a0weeks and the RVGA at 7\u00a0weeks. No between\u2010group differences were found regarding activity level (ActiGraph) or the 10MWT\u2010preferred or slow speed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with standard care, GroupCoreDIST significantly improved walking immediately after the intervention for up to 24\u00a0weeks of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.1798","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T07:09:20Z","timestamp":1562137760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Group\u2010based, individualized, comprehensive core stability and balance intervention provides immediate and long\u2010term improvements in walking in individuals with multiple sclerosis: A randomized controlled 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