{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:53:52Z","timestamp":1787313232020,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The bubble\u2010positive expiratory pressure (PEP) device may be used for sputum clearance in people with daily sputum production. However, this device has never been studied in people with bronchiectasis. Hence, the objective of this study was to compare the effect of bubble\u2010PEP device, the active cycle of breathing technique (ACBT) and no intervention (control) on sputum clearance in people with bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, randomised cross\u2010over trial with concealed allocation, assessor blinding and intention\u2010to\u2010treat analysis. Adult participants with stable bronchiectasis and productive of sputum daily were recruited. Participants performed 30\u2010min of bubble\u2010PEP, ACBT or control in random order whilst sitting, followed by 60\u2010min of quiet sitting, on three separate days at the same time within a 10\u2010day period. Primary outcome measure was wet weight of expectorated sputum during 30\u2010min intervention, 60\u2010min post intervention and total wet weight (30 min plus 60 min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010five\u2010participants (11 males, mean [standard deviation] age 75 [8] years, forced expiratory volume in 1 s 72 [20] % predicted) were recruited and 34 completed the study. There was no significant difference in sputum wet weight between bubble\u2010PEP and ACBT during 30\u2010min intervention (mean difference [95% confidence interval]) \u22120.59\u2009g [\u22121.37, 0.19] and total wet weight (0.74\u2009g [\u22120.54, 2.02]). Sputum wet weight was significantly greater in bubble\u2010PEP than ACBT at 60\u2010min post intervention (1.33\u2009g [0.19, 2.47]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sputum wet weight was significantly greater with bubble\u2010PEP than control at all time periods, and greater than ACBT at 60\u2010min\u2010post. Bubble\u2010PEP could be considered an alternative sputum clearance technique to ACBT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.1836","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T18:39:29Z","timestamp":1583001569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bubble\u2010positive expiratory pressure device and sputum clearance in bronchiectasis: A randomised cross\u2010over study"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-6632","authenticated-orcid":false,"given":"Mary D.","family":"Santos","sequence":"first","affiliation":[{"name":"Physiotherapy Department Prince of Wales Hospital  Randwick New South Wales Australia"},{"name":"Faculty of Health Sciences, Discipline of Physiotherapy The University of Sydney  Lidcombe New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree A.","family":"Milross","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Discipline of Physiotherapy The University of Sydney  Lidcombe New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Respiratory and Sleep Medicine Department Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Alison","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Discipline of Physiotherapy The University of Sydney  Lidcombe New South Wales Australia"},{"name":"Sydney Local Health District  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.171"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10289"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0360-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972306074481"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"108","article-title":"Effects of ELTGOL and flutter VRP1 on the dynamic and static pulmonary volumes and on the secretion clearance of patients with bronchiectasis","volume":"16","author":"Guimaraes F. 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