{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:25:12Z","timestamp":1778549112698,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Measurement of movement quality is essential to distinguish motor recovery patterns and optimize rehabilitation strategies post\u2010stroke. Recently, the Stroke Recovery and Rehabilitation Roundtable Taskforce (SRRR) recommended four kinetic and kinematic performance assays to measure upper extremity (UE) movements and distinguish behavioral restitution and compensation mechanisms early post\u2010stroke. The purpose of this study is to develop and validate a prediction model to analyze the added prognostic value of performance assays over clinical variables assessed up to 1\u2010month post stroke for predicting recovery of UE motor impairment, capacity and quality of movement (QoM) measured at 3\u00a0months post\u2010stroke onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, 120 stroke survivors will be recruited within seven days post\u2010stroke. Candidate predictors such as baseline characteristics, demographics and performance assays as per SRRR recommendations along with tonic stretch reflex threshold will be measured up to 1\u2010month post\u2010stroke. Upper extremity motor recovery will be evaluated in terms of motor impairment (Fugl\u2010Meyer assessment for UE), UE capacity measured with Action Research Arm Test (ARAT) and QoM (movement smoothness in the form of peak metrics [PM]) assessed with a reach\u2010to\u2010grasp\u2010to\u2010mouth task (mimicking a drinking task) at 3\u00a0months post\u2010stroke. Three multivariable linear regression models will be developed to predict factors responsible for the outcomes of Fugl\u2010Meyer assessment for upper extremity (FM\u2010UE), ARAT and movement quality. The developed models will be internally validated using a split\u2010sample method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study will provide a validated prediction model inclusive of clinical and performance assays that may assist in prediction of UE motor recovery. Predicting the amount of recovery and differentiating between behavioral restitution and compensation (as reflected by the FM\u2010UE, QoM and ARAT) would enable us in realistic goal formation and planning rehabilitation. It would also help in encouraging patients to partake in early post\u2010stroke rehabilitation thus improving the\u00a0recovery potential.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pri.1937","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:08:32Z","timestamp":1642410512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predicting post\u2010stroke motor recovery of upper extremity using clinical variables and performance assays: A prospective cohort study protocol"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0486-7811","authenticated-orcid":false,"given":"Sanjukta","family":"Sardesai","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Solomon M","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5795-3812","authenticated-orcid":false,"given":"Ashokan","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Sharjah College of Health Sciences  Sharjah United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasudeva","family":"Guddattu","sequence":"additional","affiliation":[{"name":"Department of Data Science Prasanna School of Public Health Manipal Academy of Higher Education  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankar Prasad","family":"Gorthi","sequence":"additional","affiliation":[{"name":"Bharati Vidyapeeth Deemed University Medical College  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Neurology Kasturba Hospital Manipal Academy of Higher Education  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-2584","authenticated-orcid":false,"given":"Senthil","family":"Kumaran D","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968313491008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6943.1552"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-O"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017711816"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24472"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.07.215"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1603-177"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.5.940"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968309356091"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319826050"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968317714576"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24510"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/1650197771331"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-22-08542.2000"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023006"},{"key":"e_1_2_9_18_1","volume-title":"Recovery after stroke: Not so proportional after all?","author":"Hope T. 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